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Fluorescent Analogs of Biomolecular Building Blocks, 1ed
Fluorescent Biomolecules and their Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.
Fluorescence spectroscopy, an established and highly sensitive analytical technique, has been extensively used by the scientifc community for many years. For decades, however, the majority of users have relied on a limited number of established ﬂuorophores, either naturally occurring or of synthetic origin. This has dramatically changed in recent years.
Major technological advances in ﬂuorescence-based instrumentation and techniques, including single-molecule spectroscopy, have triggered a renewed interest in the synthesis and development of new ﬂuorescent probes and labels. Two major paths have been taken that are fundamentally related to the above-mentioned two (i.e., of biosynthetic or synthetic origin) but differ in their accommodation of the challenges presented by modern techniques and contemporary scientifc questions. A particularly intriguing and emerging area of research, which is highlighted in this book, is the fabrication of minimally perturbing ﬂuorescent analogs of otherwise nonemissive biological building blocks, including amino acids, lipids, and nucleosides.
Chapter 1 Fluorescence Spectroscopy
Chapter 2 Naturally Occurring and Synthetic Fluorescent Biomolecular Building Blocks
Chapter 3 Polarized Spectroscopy with Fluorescent Biomolecular Building Blocks
Chapter 4 Fluorescent Proteins: The Show Must go on!
Chapter 5 Design and Application of Autofluorescent Proteins by Biological Incorporation of Intrinsically Fluorescent Noncanonical Amino Acids
Chapter 6 Fluoromodules: Fluorescent Dye-Protein Complexes for Genetically Encodable Labels
Chapter 7 Design of Environmentally Sensitive Fluorescent Nucleosides and their Applications
Chapter 8 Expanding The Nucleic Acid Chemist’s Toolbox: Fluorescent Cytidine Analogs
Chapter 9 Synthesis and Fluorescence Properties of Nucleosides with Pyrimidopyrimidine-Type Base Moieties
Chapter 10 Forster Resonance Energy Transfer [FRET} Between Nucleobase Analogues-a Tool for Detailed Structure and Dynamics Investigations
Chapter 11 Fluorescent Purine Analogs that Shed Light on DNA Structure and Function
Chapter 12 Design and Photophysics of Environmentally Sensitive Isomorphic Fluorescent Nucleosides
Chapter 13 Site-Specific Fluorescent Labeling of Nucleic Acids by Genetic Alphabet Expansion Using Unnatural Base Pair Systems
Chapter 14 Fluorescent C-Nucleosides and their Oligomeric Assemblies
Chapter 15 Membrane Fluorescent Probes: Insights and Perspectives
Chapter 16 Lipophilic Fluorescent Probes: Guides to the Complexity of Lipid Membranes
Chapter 17 Fluorescent Neurotransmitter Analogs
لینک کوتاه : https://bookbaz.ir/?p=39128
نویسنده : Marcus Wilhelmsson , Yitzhak Tor
ناشر : Wiley; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 475
(ISBN) شابک : 1118175867
قیمت کتاب درآمازون : $175.00
حجم فایل : 10 MB