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Antibiotics: Challenges, Mechanisms, Opportunities, 1ed
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
This book provides all the information needed to understand antibiotic genetics, biochemistry, mechanism of action and resistance. Most importantly, Walsh & Wencewicz are optimistic of the prospects of the discovery of novel therapeutic agents obtained by the manipulation of strains and biosynthetic pathways. This beautifully written book deserves to be read and implemented by everyone, especially the pessimists who believe that the antibiotic era has ended. In Antibiotics: Challenges, Mechanisms, Opportunities, Walsh & Wencewicz provide the definitive, ultimate compendium of everything antibiotic. –Julian Davies, Professor of Microbiology and Immunology, Life Sciences Institute, University of British Columbia Vancouver
۱ Antibiotics: Initial Concepts and Considerations
۲ Major Classes of Antibiotics and Their Modes of Action
۳ Assembly of the Peptidoglycan Layer of Bacterial Cell Walls
۴ Antibiotics That Block Peptidoglycan Assembly and Integrity
۵ Antibiotics That Disrupt Membrane Integrity
۶ Antibiotics That Block Protein Synthesis
۷ Antibiotics That Target DMA and RNA Information Transfer
۸ Antibiotics That Block Biosynthesis of the DMA Building Block Deoxythymidylate
۹ Bacterial Antibiotic Resistance: Overview
۱۰ Antibiotic Resistance: Modification or Destruction of the Antibiotic
۱۱ Antibiotic Resistance via Membrane Efflux Pumps
۱۲ Resistance via Target Modification
۱۳ Tuberculosis: A Formidable Challenge for Antibiotic Therapy
۱۴ Antibiotic Biosynthesis: Principles
۱۵ Biosynthesis of Peptide Antibiotics
۱۶ Biosynthesis of Polyketide Antibiotics
۱۷ Biosynthesis of Oligosaccharide, Isoprenoidr and C-P Antibiotic Classes
۱۸ Underexploited Pathways and Targets for Antibiotics
۱۹ Prospects for New Molecules and New Targets
لینک کوتاه : https://bookbaz.ir/?p=51923
نویسنده : Christopher Walsh , Timothy Wencewicz
ناشر : Amer Society for Microbiology; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 490
(ISBN) شابک : 1555819303
قیمت کتاب درآمازون : $114.16
حجم فایل : 21 MB