دانلود کتاب اپتوژنتیک
Optogenetics, 1ed

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Discovered little more than a decade ago, optogenetics – a revolutionary technique combining genetic and optical methods to observe and control the function of neurons – is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson’s disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

Review

‘Optogenetics has transformed neuroscience and has become a key element of the toolkit used by thousands of labs worldwide. If anyone needs convincing that the field of optogenetics has come of age, this book provides compelling evidence. Written by leading experts in the field and covering the gamut of optogenetics research from tool development and use in basic research through to translational applications, Optogenetics exemplifies how this technique now illuminates all areas of neuroscience research.’ Michael Hausser, University College London,

”Let there be light’. Or more precisely, deliver the needed wavelength at appropriate power, with high temporal and spatial resolution if you want to figure out how brain circuits work. This volume has many excellent chapters and the right toolbox for the job.’ György Buzsáki, Neuroscience Institute and Langone Medical Center, New York University

‘Optogenetics is a unique compilation of articles by some of the key experts in the field covering the entire breadth of topics from molecular mechanisms, via hands-on application tips all the way to clinical use and ethical implications as well as a detailed and accurate historical perspective. For this still rapidly developing field it will become a must-read and core reference for novices and experts alike.’ Andreas Schaefer, he Francis Crick Institute, London

‘Both the expert and novice, alike, will find this to be a valuable resource that covers multiple aspects of the Optogenetics field, from its history through to current scientific and potential clinical applications.’ Michelle M. Sidor, Novartis Institutes for Biomedical Research, Massachusetts

Contents

۱. Introduction to Optogenetics: From Neuronal Function to Mapping and Disease Biology
۲. Uncovering Key Neurons for Manipulation in Mammals
۳. From Connectome to Function: Using Optogenetics to Shed Light on the Caenorhabditis elegans Nervous System
۴. From Synapse to Behavior: Optogenetic Tools for the Investigation of the Caenorhabditis elegans Nervous System
۵. Using Optogenetics In Vivo to Stimulate Regeneration in Xenopus laevis
۶. Sodium and Engineered Potassium Light-Driven Pumps
۷. Methods for Simultaneous Electrophysiology and Optogenetics In Vivo
۸. Application of an Optogenetic Technique to a Study of Activity-dependent Axon Growth in the Developing Cortex
۹. Development of an Optogenetic Tool to Regulate Protein Stability In Vivo
۱۰. Photoactivatable Nucleotide Cyclases for Synthetic Photobiology Applications
۱۱. Bioluminescence Activation of Light-sensing Molecules
۱۲. Optogenetics for Neurological Disorders: What Is the Path to the Clinic?
۱۳. Optogenetic Control of Astroglia
۱۴. Optogenetics for Neurohormones and Neuropeptides: Focus on Oxytocin
۱۵. Optogenetic Approaches to Investigating Brain Circuits
۱۶. Optogenetic Mapping of Neuronal Connections and their Plasticity
۱۷. Optogenetics to Study Reward Learning and Addiction
۱۸. Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disorders
۱۹. Optogenetics Research in Behavioral Neuroscience: Insights into the Brain Basis of Reward Learning and Goal-directed Behavior
۲۰. Toward an Optogenetic Therapy for Epilepsy
۲۱. Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Function
۲۲. Optogenetics in Treating Retinal Disease
۲۳. Optogenetics for Vision Recovery: From Traditional to Designer Optogenetic Tools
۲۴. A Promise of Vision Restoration
۲۵. Holographic Optical Neural Interfacing with Retinal Neurons
۲۶. Strategies for Restoring Vision by Transducing a Channelrhodopsin Gene into Retinal Ganglion Cells
۲۷. Optogenetic Dissection of a Top-down Prefrontal to Hippocampus Memory Circuit
۲۸. Optogenetic Dissection of Sleep–Wake Control: Evidence for a Thalamic Control of Sleep Architecture
۲۹. Optogenetics and Auditory Implants
۳۰. Optogenetic Stimulation for Cochlear Prosthetics
۳۱. The Role of Amino Acids in Neurodegenerative and Addictive Diseases
۳۲. Optogenetics in Deep Brain Stimulation: Ethical Considerations

قیمت : 3000 تومان
لینک کوتاه : https://bookbaz.ir/?p=101995
نویسنده : Krishnarao Appasani
ناشر : Cambridge University Press; 1 edition
سال انتشار : 2017
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 519
(ISBN) شابک : 1107053013
قیمت کتاب درآمازون : $108.00
حجم فایل : 10 MB

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