دانلود کتاب بکارگیری فناوری ژنومی و پروتئوم ریزآرایه در کشف دارو
Applying Genomic and Proteomic Microarray Technology in Drug Discovery, 2ed
Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications.
Updated and revised to reflect recent progress in the field, the second edition discusses:
- Expanded omics-driven applications, including the areas of metabolomics and chemical biology
- The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments
- Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays
- Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented
- The development of the gene expression microarray and representative applications
- The development of protein microarray technology, including its history and key applications
Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons.
Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.
A basic reference on the benefits of microarray technology in drug discovery, this publication offers a detailed perspective and insight into the present and future uses of this technology.
Anticancer Research –This text refers to an out of print or unavailable edition of this title.
About the Author
Robert S. Matson is president and co-founder of QuantiScientifics, LLC. The company is involved in the commercialization of multiplexed assays for life science, clinical research, and in vitro diagnostics. Previously, Matson was involved in the research and development of microarray technologies, detection chemistries, as well as point-of-care devices for more than 17 years while at Beckman Coulter, Inc. He participated in the National Institute of Standards and Technology’s (NIST) Advanced Technology Program sponsored Genosensor Consortium and collaborated with Sir Edwin Southern on the development of an in situ oligonucleotide array synthesis platform for the corporation. Other work included development of the A۲ MicroArray System, a microplate-based array platform for multiplexed micro-ELISA, which QuantiScientifics recently licensed for commercialization.
Chapter 1 – Omics and Microarrays Revisited
Chapter 2 – Commercial Microarrays
Chapter 3 – Supports and Surface Chemistries
Chapter 4 – Arraying Processes
Chapter 5 – Gene Expression: Microarray-Based Applications
Chapter 6 – Protein Microarray Applications
Chapter 7 – Multiplex Assays
لینک کوتاه : https://bookbaz.ir/?p=33719
نویسنده : Robert S. Matson
ناشر : CRC Press; 2 edition
سال انتشار : 2014
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 312
(ISBN) شابک : 1439855633
قیمت کتاب درآمازون : $150.14
حجم فایل : 8 MB