دانلود کتاب بیماری ریزاندامگان همزیست و مزمن انسان: ناترازشدن همزیستی به عنوان علت آسیب شناسی انسانی
The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology, 1ed
Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease.
The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states.
Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position.
- Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota
- Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition
- Explores the relationship humans have with their microbiota, and its significance in human health and disease
- Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease
Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.
About the Author
Luigi Nibali is a Senior Clinical Lecturer in the Clinical Oral Research Centre, Institute of Dentistry, Queen Mary University London in London, UK.
Brian Henderson is a Professor of Microbial Diseases in the School of Life and Medical Sciences at University College London in London, UK.
۱ The human microbiota: an historical perspective
۲ An introduction to microbial dysbiosis
۳ The gut microbiota: an integrated interactive system
۴ The oral microbiota
۵ The skin microbiota
۶ Metagenomic analysis of the human microbiome
۷ Systems biology of bacteria-host interactions
۸ Bacterial biofilm formation and immune evasion mechanisms
۹ Co-evolution of microbes and immunity and its consequences for modern-day life
۱۰ How viruses and bacteria have shaped the human genome: the implications for disease
۱۱ The microbiota as an epigenetic control mechanism
۱۲ The emerging role of propionibacteria in human health and disease
۱۳ The periodontal diseases: microbial diseases or diseases of the host response?
۱۴ The polymicrobial synergy and dysbiosis model of periodontal disease pathogenesis
۱۵ New paradigm in the relationship between periodontal disease and systemic diseases: effects of oral bacteria on the gut microbio
۱۶ The vaginal microbiota in health and disease
۱۷ Reactive arthritis: the hidden bacterial connection
۱۸ Rheumatoid arthritis: the bacterial connection
۱۹ Inflammatory bowel disease and the gut microbiota
۲۰ Ankylosing spondylitis,, klebsiella and the low-starch diet
۲۱ Microbiome of chronic plaque psoriasis
۲۲ Liver disease: interactions with the intestinal microbiota
۲۳ The gut microbiota: a predisposing factor in obesity, diabetes and atherosclerosis
۲۴ The microbiota and susceptibility to asthma
۲۵ Microbiome and cancer
۲۶ Colorectal cancer and the microbiota
۲۷ The gut microbiota and the CMS: an old story with a new beginning
۲۸ Genetic dysbiosis: how host genetic variants may affect microbial biofilms
۲۹ Diet and dysbiosis
۳۰ Probiotics and prebiotics: what are they and what can they do for us?
۳۱ The microbiota as target for therapeutic intervention in pediatric intestinal diseases
۳۲ Microbial therapy for cystic fibrosis
لینک کوتاه : https://bookbaz.ir/?p=54656
نویسنده : Luigi Nibali , Brian Henderson
ناشر : Wiley-Blackwell; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 559
(ISBN) شابک : 1118982878
قیمت کتاب درآمازون : $124.45
حجم فایل : 8 MB