دانلود کتاب بیوفناوری دارویی و فارماکوکینتیک کاربردی
Applied Biopharmaceutics & Pharmacokinetics, 7ed

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The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics―now fully updated.

The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts.

  • Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them
  • Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency
  • Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy

Written by authors who have both academic and clinical experience, Applied  Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate  the pharmacokinetic models and parameters that best describe the process of drug  absorption, distribution, and elimination. The book also helps you work with pharmacokinetic  and biopharmaceutic parameters to design and evaluate dosage   regimens of drugs. In the seventh edition of this must-have interactive learning tool, most  of the chapters are updated to reflect our current understanding of complex issues  associated with safe and efficacious drug therapy.

About the Author

Leon Shargel, PhD is vice president of biopharmaceutics at Eon Labs, Inc. in Wilson, North Carolina.

Andrew B.C. Yu, PhD, RPh formerly a professor at the Albany College of Pharmacy is currently with the US Food and Drug Administration in Rockville, Maryland.

Contents

۱. Introduction to Biopharmaceutics and Pharmacokinetics
۲. Mathematical Fundamentals in Pharmacokinetics
۳. Biostatistics
۴. One-Compartment Open Model: Intravenous Bolus Administration
۵. Multicompartment Models: Intravenous Bolus Administration
۶. Intravenous Infusion
۷. Drug Elimination, Clearancer and Renal Clearance
۸. Pharmacokinetics of Oral Absorption
۹. Multiple-Dosage Regimens
۱۰. Nonlinear Pharmacokinetics
۱۱. Physiologic Drug Distribution and Protein Binding
۱۲. Drug Elimination and Hepatic Clearance
۱۳. Pharmacogenetics and Drug Metabolism
۱۴. Physiologic Factors Related to Drug Absorption
۱۵. Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance
۱۶. Drug Product Performance,In Vivo: Bioavailability and Bioequivalence
۱۷. Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence
۱۸. Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy
۱۹. Modified-Release Drug Products and Drug Devices
۲۰. Targeted Drug Delivery Systems and Biotechnological Products
۲۱. Relationship Between Pharmacokinetics and Pharmacodynamics
۲۲. Application of Pharmacokinetics to Clinical Situations
۲۳. Application of Pharmacokinetics to Specific Populations: Geriatric, Obese, and Pediatric Patients
۲۴. Dose Adjustment in Renal and Hepatic Disease
۲۵. Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analysis

قیمت : 5000 تومان
لینک کوتاه : https://bookbaz.ir/?p=46847
نویسنده : Leon Shargel , Andrew Yu
ناشر : McGraw-Hill Education / Medical; 7 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 929
(ISBN) شابک : 0071830936
قیمت کتاب درآمازون : $64.50
حجم فایل : 15 MB

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۵۰۰۰ تـومان – خرید