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Paternal Influences on Human Reproductive Success, 1ed

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Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides ‘cutting edge’ data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis.

Book Description

This book is ideal for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis. Additionally, the book investigates the role of advanced paternal age on offspring, which has profound implications for a large percentage of couples.

About the Author

Douglas T. Carrell is Professor of Surgery, Obstetrics and Gynecology, and Genetics, and Director of the Andrology and IVF Laboratories, at University of Utah Health Care, Salt Lake City, Utah, USA.

Contents

۱. The reproductive fitness of the human male gamete
۲. The sperm genome: effect of aneuploidies, structural variations, single nucleotide changes, and DNA damage on embryogenesis and development
۳. The sperm epigenome: a role in embryogenesis and fetal health?
۴. Imprinted gene anomalies in sperm
۵. Has the renewed interest in sperm RNA led to fresh insights? A critical review and hypothesis
۶. The role of the sperm centrosome in reproductive fitness
۷. The male biological clock
۸. The role of aging on fecundity in the male
۹. Aging, DNA damage, and reproductive outcome
۱۰. Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer
۱۱. Sexual function in the aging male
۱۲. Supplements and replacement therapies for the aging male and their effects on reproductive fitness
۱۳. Environment and lifestyle effects on fertility
۱۴. Obesity and male infertility: is there an effect on embryogenesis?
۱۵. Intracytoplasmic sperm injection: does the sperm matter?
۱۶. Sperm selection and ART outcome: a means to overcome the effects of aging and abnormal spermatogenesis?
۱۷. Variability of human semen quality: caution in interpreting semen analysis data
۱۸. Semen characteristics and aging: technical considerations regarding variability

قیمت : 3000 تومان
لینک کوتاه : https://bookbaz.ir/?p=106145
نویسنده : Douglas T. Carrell
ناشر : Cambridge University Press; 1 edition
سال انتشار : 2013
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 222
(ISBN) شابک : 9781107024489
قیمت کتاب درآمازون : $57.85
حجم فایل : 4 MB

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۳۰۰۰ تـومان – خرید