دانلود کتاب تست سم شناسی ژنتیکی: راهنمای آزمایشگاهی
Genetic Toxicology Testing: A Laboratory Manual, 1ed

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Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria.

An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.

  • Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab
  • Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results
  • Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP)
  • Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

About the Author

Ray Proudlock graduated from Thames Polytechnic in Woolwich in 1974. His first laboratory jobs involved plant tissue culture and DNA turnover in cultured lymphocytes. Subsequently, he performed and supervised a wide range of genetic toxicology assays at Huntingdon Life Sciences (HLS, now Envigo), the third largest contract toxicology company in the world. He specialized in practical improvement of the quality and efficiency of test methods, many of which are still in routine use including Ames, in vivo micronucleus, in vitro and in vivo chromosome aberration. While at Huntingdon, he was awarded a master’s degree for work on in vitro and in vivo UDS by Swansea University, which remains the academic center of excellence for genetox in the UK.

Contents

Chapter 1: A Practical Guide to Genetic Toxicology Testing
Chapter 2: General Recommendations
Chapter 3: Formulation of Test Articles
Chapter 4: The Bacterial Reverse Mutation Test
Chapter 5: The Mouse Lymphoma TK Assay
Chapter 6: The In Vitro Micronucleus Assay
Chapter 7: The In Vitro Chromosome Aberration Test
Chapter 8: The In Vivo Rodent Micronudeus Assay
Chapter 9: The Rodent Bone Marrow Chromosomal Aberration Test
Chapter 10: The In Vivo Comet Assay Test
Chapter 11: The Pig-a Endogenous Gene Mutation Assay

قیمت : 3000 تومان
لینک کوتاه : https://bookbaz.ir/?p=115269
نویسنده : Ray Proudlock
ناشر : Academic Press; 1 edition
سال انتشار :
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 460
(ISBN) شابک : 0128007648
قیمت کتاب درآمازون : $81.61
حجم فایل : 5 MB

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