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The Practice of Medicinal Chemistry, 4ed

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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough  treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.

With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

  • Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field
  • Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts
  • Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research
  • An image bank is available for instructors at www.textbooks.elsevier.com

Review

“…provides a diverse, multi-authored yet comprehensive update on the current state of the art in the science of medicinal chemistry…highly recommended for graduate students in the medicinal chemistry and drug discovery sciences.” —Drug Development Research

Praise for the Third Edition: “The third edition of this book, useful to seasoned medicinal chemists as well as to chemists entering the academic or industrial laboratories, provides a hands-on overview of the drug discovery process. This edition differs from the previous two editions by having been updated to reflect developments in the past 5 years, and it includes 11 new chapters. I found this book to be unique, well organized, and overall a useful addition to the medicinal chemistry literature. Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process.” –John L. Neumeyer, Harvard Medical School, Journal of Medicinal Chemistry

“…a diverse, multi-authored yet comprehensive update on the current state of the art in the science of medicinal chemistry…highly recommended for graduate students in the medicinal chemistry and drug discovery sciences.”–Drug Development Research,The Practice of Medicinal Chemistry, Fourth Edition

About the Author

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the “Centre d’Etudes Physio-biologiques Appliquées à la Marine” in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine.

Contents

Chapter 1. Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems
Chapter 2. Evaluation of the Biological Activity of Compounds: Techniques and Mechanism of Action Studies
Chapter 3. Drug Targets, Target Identification, Validation, and Screening
Chapter 4. Strategies in the Search for New Lead Compounds or Original Working Hypotheses
Chapter 5. Natural Products as Pharmaceuticals and Sources for Lead Structures
Chapter 6. In Silico Screening: Hit Finding from Database Mining
Chapter 7. Fragment-Based Drug Discovery
Chapter 8. Molecular Variations Based on Isosteric Replacements
Chapter 9. Ring Transformations
Chapter 10. Macrocycles: Under-Explored and Poorly Exploited Drug Class Despite the Proven Therapeutic Potential
Chapter 11. Conformational Restriction and Steric Hindrance in Medicinal Chemistry
Chapter 12. Application Strategies for the Primary Structure–Activity Relationship Exploration
Chapter 13. Substituent Groups
Chapter 14. The Role of Functional Groups in Drug–Receptor Interactions
Chapter 15. Compound Properties and their Influence on Drug Quality
Chapter 16. Pharmacological Space
Chapter 17. Systems Biology: A New Paradigm for Drug Discovery
Chapter 18. Optical Isomerism in Drugs
Chapter 19. Multitarget Drugs: Strategies and Challenges for Medicinal Chemists
Chapter 20. Selective Optimization of Side Activities (SOSA) in Drug Discovery
Chapter 21. Pharmacophore Identification and Pseudo-Receptor Modeling
Chapter 22. Protein Crystallography and Drug Discovery
Chapter 23. Physiological Aspects Determining the Pharmacokinetic Properties of Drugs
Chapter 24. Biotransformation Reactions and their Enzymes
Chapter 25. Biotransformations Leading to Toxic Metabolites: Chemical Aspects
Chapter 26. Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs
Chapter 27. Strategies for Enhancing Oral Bioavailability and Brain Penetration
Chapter 28. Designing Prodrugs and Bioprecursors
Chapter 29. Drug Delivery with Organic Solvents or Colloidal Dispersed Systems
Chapter 30. Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
Chapter 31. Improving the Water-Solubility of Compounds by Molecular Modification to Disrupt Crystal Packing
Chapter 32. Chemical and Physicochemical Approaches to Solve Formulation Problems
Chapter 33. Discover a Drug Substance, Formulate, and Develop It to a Product
Chapter 34. Drug Nomenclature
Chapter 35. Web Alert: Using the Internet for Medicinal Chemistry
Chapter 36. Protection of Inventions in Medicinal Chemistry

قیمت : 6000 تومان
لینک کوتاه : https://bookbaz.ir/?p=54645
نویسنده : Camille Georges Wermuth
ناشر : Academic Press; 4 edition
سال انتشار : 2015
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 903
(ISBN) شابک : 0124172059
قیمت کتاب درآمازون : $146.25
حجم فایل : 20 MB

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