Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.
From the Back Cover
Drug therapy via inhalation is at the cutting edge of modern drug delivery research. It is a noninvasive, rapid, and effective way to deliver therapeutic agents both locally and systemically. However, there are challenges associated with the formulation design of inhalation products, including understanding interactions that exist between the active pharmaceutical ingredients (APIs), excipients, and the device.
Advances and Challenges in Pulmonary Drug Delivery describes the most pertinent issues in the selection
and design of formulation components and device which impact upon patient usability and clinical effectiveness. The constraints involved with the delivery of APIs to both adult and paediatric patients are covered. The science relating to the formulation of micro- and nanoparticles, macromolecules, and antibiotics and chemotherapeutic agents is described. The importance of the chemistry and physicochemical properties of the excipient in increasing delivery efficiency is considered in detail. The evaluation of inhalers containing poorly soluble APIs and testing the dissolution of such formulations is also reviewed. Finally, the book provides a detailed account of research strategies for the future development of inhaled medicines.
Intended for researchers and advanced students in pharmacy, as well as researchers in respiratory formulations and drug delivery in the pharmaceutical industry, the book enables readers to develop a deep understanding of the key aspects of inhalation formulations.
About the Author
GARY P. MARTIN Institute of Pharmaceutical Science, King’s College London, UK
لینک کوتاه : https://bookbaz.ir/?p=9190
نویسنده : Ali Nokhodchi , Gary P. Martin
ناشر : Wiley; 1 edition
سال انتشار : 2015
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 384
(ISBN) شابک : 1118799542
قیمت کتاب درآمازون : $180.00
حجم فایل : 4 MB