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Handbook of Developmental Neurotoxicology, 2ed

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Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.

  • Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition
  • Contains new chapters that focus on subjects recent to the field
  • Includes well-illustrated material, with diagrams, charts, and tables
  • Contains compelling case studies and chapters written by world experts

About the Author

Dr. Slikker is the Director of FDA’s National Center for Toxicological Research (NCTR). He received his Ph.D. in Pharmacology and Toxicology from the University of California at Davis. Dr. Slikker holds Adjunct Professorships in the Departments of Pediatrics, and Pharmacology and Toxicology at the University of Arkansas for Medical Sciences. He has held committee chairmanships or elected offices in several scientific societies, including the Teratology Society (serving as President) and the American Society for Pharmacology and Experimental Therapeutics (Chair, Developmental Pharmacology Section and member of the Program Committee) and co-founder and past President of the MidSouth Computational Biology and Bioinformatics Society. He is currently Associate Editor for NeuroToxicology and Toxicological Sciences and is the past President of The Academy of Toxicological Sciences, the Society of Toxicology (Presidential term ended 2013), recipient of the 2014 George H. Scott Memorial Award from The Toxicology Forum and invited to present the Warkany Lecture at the 2015 annual meeting of the Teratology Society. Dr. Slikker has authored or co-authored over 300 publications in the areas of transplancental pharmacokinetics, developmental neurotoxicology, neuroprotection, systems biology, and risk assessment. He has also served on several national/international advisory panels for the International Life Sciences Institute (ILSI)/Health and Environmental Sciences Institute (HESI), Chemical Industry Institute of Toxicology (CIIT) Centers for Health Research, Environmental Protection Agency (EPA), National Institute of Environmental Health Sciences (NIEHS), National Academy of Sciences (NAS), National Institutes of Health (NIH) and World Health Organization (WHO).

Contents

۱. Brain Morphogenesis and Developmental Neurotoxicology
۲. Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development
۳. Neurite Development and Neurotoxicity
۴. Myelin: Structure, Function, Pathology and Targeted Therapeutics
۵. Neurotrophic Factors
۶. Serotonin Signaling as a Target for Craniofacial Embryotoxicity
۷. Neurotoxic and neurotrophic effects of GABAergic agents on the developing brain
۸. Neural stem cell biology and application to developmental neurotoxicity assessment
۹. Apoptosis as a Mechanism of Developmental Neurotoxicity
۱۰. Periods of Susceptibility:  Interspecies Comparison of Developmental Milestones during Ontogenesis of the Central Nervous System
۱۱. Modeling the Neurovascular Unit in vitro and in silico
۱۲. Zebrafish Models of Developmental Biology and Toxicology
۱۳. Using Caenorhabditis elegans to Study Neurotoxicity
۱۴. Human 3D in vitro Models for Developmental Neurotoxity
۱۵. Ontogeny of Monoamine Neurotransmitters
۱۶. Developmental Toxicity within the Central Cholinergic Nervous System
۱۷. Ontogeny of Second Messenger Systems
۱۸. The NMDA Receptors: Physiology and Neurotoxicology in the Developing Brain
۱۹. Physiologically Based Pharmacokinetic (PBPK) Models
۲۰. Blood-Brain Barrier: Physiological and Functional Considerations
۲۱. Toxicological Mechanisms of Engineered Nanomaterials: Role of Material Properties in Inducing Different Biological Responses
۲۲. Food and Nutrient Exposure Throughout the Life Span: How Does What We Eat Translate into Exposure, Deficiencies, and Toxicities?
۲۳. The Microbiome Gut-Brain Axis
۲۴. Drug and Chemical Contaminants in Breast Milk: Effects on Neurodevelopment of the Nursing Infant
۲۵. Behavioral Phenotyping in Developmental Neurotoxicology – Simple Approaches using Unconditioned Behaviors in Rodents
۲۶. Psychometric Tools to Study Cognition, Sensory Functioning and Social Behavior in Infant and Adolescent Nonhuman Primates
۲۷. Automated assessment of cognitive function in nonhuman primates
۲۸. Determining the validity of pre-clinical behavioral assessments for extrapolation to a clinical setting
۲۹. Behavioral Outcome as a Primary Organizing Principle for Mechanistic Data in Developmental Neurotoxicity
۳۰. Evaluation of the Human Newborn Infant
۳۱. Neuropsychological Assessment of Children in Studies of Developmental Neurotoxicity
۳۲. Neurodevelopmental Assessment of the Older Infant and Child
۳۳. Longitudinal Studies of the Effects of Prenatal Cocaine Exposure on Development and Behavior
۳۴. Assessment of Case Reports and Clinical Series
۳۵. Fetal Minamata Disease: A Human Episode of Congenital Methylmercury Poisoning
۳۶. The Developmental Neurotoxicity of Cadmium
۳۷. Developmental Neurotoxicology of Lead –  Neurobehavioral and Neurological Impacts
۳۸. Fetal Alcohol Spectrum Disorder
۳۹. Developmental Neurotoxicity of Nicotine and Tobacco
۴۰. Developmental Neurobehavioral Neurotoxicity of Insecticides
۴۱. Developmental Exposure to Polychlorinated Biphenyls Induces Deficits in Inhibitory Control and May Enhance Substance Abuse Risk
۴۲. Developmental Neurotoxicity of General Anesthetics
۴۳. Maternal Drug Abuse and Adverse Effects on Neurobehavior of Offspring
۴۴. Developmental Neurotoxicology of Antiepileptic Drugs
۴۵. Current Approaches to Risk Assessment for Developmental Neurotoxicity
۴۶. Animal/Human Concordance
۴۷. Physiologically based pharmacokinetic models in the risk assessment of developmental neurotoxicants
۴۸. Application of Quantitative dose response data in risk assessment and the incorporation of high throughput data

قیمت : 6000 تومان
لینک کوتاه : https://bookbaz.ir/?p=100054
نویسنده : William Slikker Jr. , Merle G. Paule
ناشر : Academic Press; 2 edition
سال انتشار : 2018
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 591
(ISBN) شابک : 0128094052
قیمت کتاب درآمازون : $213.75
حجم فایل : 14 MB

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