دانلود کتاب سلول های بنیادی سرطان: فلسفه و درمان
Cancer Stem Cells: Philosophy and Therapies, 1ed
An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.
Rather than treat cancer by aggressively trying to eliminate all cancerous cells―with harmful side effects for patients―CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells―the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation.
To date, researchers have not agreed on the defining feature of CSCs―their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell’s relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.
Laplane places us right in the center of an urgently important discussion of cancer stem cells and the therapies that should accompany different theories. Her fresh philosophical perspective introduces us to a science in process, where the outcome is unknown and even the terms of debate remain contested. (Jane Maienschein, author of Embryos under the Microscope)
If you had doubts about the utility of philosophy for science, read this book. Its lucid exploration of stem cells will convince you that even cancer therapy can benefit from the lights of philosophy. (Michel Morange, author of A History of Molecular Biology)
Builds a much broader framework for understanding the biology of stem cells of all types…Laplane’s rigorous analyses unveil deep semantic and conceptual problems in the field…Laplane’s stemness framework should be of great value…A philosopher may indeed have straightened out the stem-cell field. (Hans Clever Nature ۲۰۱۶-۰۶-۰۹)
About the Author
Lucie Laplane is a researcher in Philosophy of Science at the Université Paris 1 Panthéon-Sorbonne and Institut Gustave Roussy.
Chapter 1. Cancer Stem Cells’ Triumph
Chapter 2. The CSC Theory
Chapter 3. Teratocarcinomas and Embryonic Stem Cells
Chapter 4. Leukemic and Hematopoietic Stem Cells
Chapter 5. Origin,. Stemnessr and Stem Cells: The Meaning of Words
Chapter 6. Stem Cell Identity
Chapter 7. If Sternness Is a Categorical or a Dispositional Property, How Can We Cure Cancers?
Chapter 8. If Sternness Is a Relational or a Systemic PropertyrHow Can We Cure Cancers?
لینک کوتاه : https://bookbaz.ir/?p=57702
نویسنده : Lucie Laplane
ناشر : Harvard University Press; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 272
(ISBN) شابک : 0674088743
قیمت کتاب درآمازون : $34.67
حجم فایل : 14 MB