دانلود کتاب سلول های تومور گردشی: جداسازی و آنالیز
Circulating Tumor Cells: Isolation and Analysis, 1ed

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Presents a range of topics in the area of Circulating Tumor Cells including their isolation and analysis

Circulating Tumor Cells (CTCs) in peripheral blood play a key role in cancer metastasis because cancer cells must transport through the circulatory system before colonizing the secondary sites.  CTCs have been advocated as potential biomarkers for cancer diagnosis, prognosis, and theragnosis or personalized medicine.  As a result, CTC isolation and analysis is an important topic in research, medical, and clinical communities.

Early chapters in Circulating Tumor Cells: Isolation and Analysis present an introduction to CTCs as well as historical perspective for readers both in and entering the field, while subsequent chapters explore a variety of state-of-the-art isolation methods, post-isolation analysis, clinical translation, and commercial platforms.

Split into five parts Circulating Tumor Cells: Isolation and Analysis features:

  • An introductory chapter presenting CTCs from historic perspectives
  • CTC isolation methods ranging from the macro- to micro-scale, from positive isolation to negative depletion, and from biological-property-enabled to physical-property-based approaches
  • Post-isolation analysis and clinical translation, including tumor heterogeneity, single cell analysis, regulatory policy, and clinical practice
  • Commercialization platforms such as CellSearch®, the only FDA-approved CTC platform, and DEPArrayTM, which is an instrument that can identify, quantify, and recover individual CTCs
  • A glossary, consisting of the definition of scientific terms related to CTCs

Because CTC isolation and analysis are important topics that have attracted much interest from academics, government agencies, and industry, this field has been the subject of many international symposia, calls-for-proposals from funding agencies, and articles in high-impact journals. The significance of CTCs and potential market values make companies and investors interested in the field.  Many researchers, as well as students will find this book a welcome addition to gain new insight to this rapidly growing field.

Z. Hugh Fan, PhD, is a professor of the Department of Mechanical and Aerospace Engineering, J. Crayton Pruitt Family Department of Biomedical Engineering, and Department of Chemistry at the University of Florida (UF), USA. Prior to joining UF in 2003, Dr. Fan was a Principal Scientist at ACLARA BioSciences Inc. and was previously a Member of the Technical Staff at Sarnoff Corp. Dr. Fan has been recognized with E.T.S. Walton Award from Science Foundation of Ireland in 2009, Fraunhofer-Bessel Research Award from Alexander von Humboldt Foundation (Germany) in 2010, and UF Research Foundation Professorship in 2014.

Contents

Chapter 1 Circulating Tumor Cells and Historic Perspectives
Chapter 2 Introduction to Microfluidics
Chapter 3 Ensemble-decision Aliquot Ranking (eDAR) for CTC Isolation and Analysis
Chapter 4 Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis
Chapter 5 Cell Separation using Inertial Microfluidics
Chapter 6 Morphological Characteristics of CTCs and the Potential for Deformability-Based Separation
Chapter 7 Microfabricated Fitter Membranes for Capture and Characterization of Circulating Tumor Cells (CTCs)
Chapter 8 Miniaturized Nuclear Magnetic Resonance Platform for Rare Cell Detection and Profiling
Chapter 9 Nanovelcro Cell-Affinity Assay for Detecting and Characterizing Circulating Tumor Cells
Chapter 10 Acoustophoresis in Tumor Cell Enrichment
Chapter 11 Photoacoustic Flow Cytometry for Detection and Capture of Circulating Melanoma Cells
Chapter 12 Selectin-Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment
Chapter 13 Aptamer-Enabled Tumor Cell Isolation
Chapter 14 Depletion of Normal Cells for CTC Enrichment
Chapter 15 Tumor Heterogeneity and Single-cell Analysis of CTCs
Chapter 16 Single-Cell Molecular Profiles and Biophysical Assessment of Circulating Tumor Cells
Chapter 17 Directing Circulating Tumor Cell Technologies Into Clinical Practice
Chapter 18 DEPArrayTM Technology for Single CTC Analysis
Chapter 19 CELL-SEARCH® Instrument Featuresr and Usage

قیمت : 4000 تومان
لینک کوتاه : https://bookbaz.ir/?p=53756
نویسنده : Z. Hugh Fan , Mark F. Vitha
ناشر : Wiley; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 480
(ISBN) شابک : 1118915534
قیمت کتاب درآمازون : $141.07
حجم فایل : 10 MB

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