دانلود کتاب فارماکولوژی عمومی و مولکولی: اصول تاثیر دارو
General and Molecular Pharmacology: Principles of Drug Action, 1ed

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With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention  to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.

•    Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students
•    Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs
•    Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties
•    Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development
•    Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

From the Back Cover

Defined by ASPET as the study of the effects of chemical agents of therapeutic value or with the potential toxicity on biological systems, pharmacology is critical to understanding how drugs can correct the biochemical abnormalities responsible for human illness. It is one of the core disciplines students need to master in order to develop effective drugs and therapeutics.

This book, the updated and enhanced English translation of a successful and multi-edition Italian text, covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention mechanisms of drug action – the fundamental basis for proper clinical use – without neglecting drug interactions, general physiological functions, and the toxicological effects of chemical compounds . As opposed to classical pharmacology textbooks, which spend more time detailing medical and therapeutic effects, the authors offer thorough discussion of drug action mechanisms at cell and molecular level and the rules governing drug pharmacokinetics and development.

The target-oriented approach within the text changes the common perception of drugs as chemical entities affecting organisms and highlights the interdisciplinary and dynamic nature of pharmacological research. As such, the book introduces pharmacologists to a more integrated view of their discipline and fosters a holistic approach to the analysis and treatment of diseases – one in which drugs are regarded as critical tools to discover new cell functions, mechanisms, and therapies.

Complementary to the main text, the book has a companion website that builds on the content within the book itself by addressing more specific subjects and methodologies. The site is ideal for readers who have mastered the basic principles and are seeking more in-depth knowledge of detailed topics.

More than just a course text for pharmacology students, this book can also be a key reference and resource for researchers and professionals involved in any aspect of drug development

About the Author

Francesco Clementi is a Professor Emeritus of Pharmacology at the University of Milan. He has been President of several national and international societies and is member of the Accademia dei Lincei, the prestigious Academy of Italian Sciences. He authored over 200 publications dealing with neurotransmitter receptors and co-edited several books on neuropharmacology and cell biology including all four editions of the Italian language version of this book, Farmacologia Generale e Molecolare.

Guido Fumagalli has been the Dean of Faculty Director of the PhD School of Translational Medicine, Vice-Provost for Research, and Vice-Provost for International Affairs at the University of Verona. He has over 80 publications in international journals to his credit along with numerous books on pharmacology and sports science

Contents

CHAPTER 1 ESSENTIAL LEXICON OF PHARMACOLOGY
CHAPTER 2 A SHORT HISTORY OF PHARMACOLOGY
CHAPTER 3 CELLULAR BASIS OF PHARMACOKINETICS
CHAPTER 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES
CHAPTER 5 DRUG DISTRIBUTION AND ELIMINATION
CHAPTER 6 DRUG METABOLISM
CHAPTER 7 CONTROL OF DRUG PLASMA CONCENTRATION
CHAPTER 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS
CHAPTER 9 RECEPTORS AND MODULATION OF THEIR RESPONSE
CHAPTER 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE
CHAPTER 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS
CHAPTER 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS
CHAPTER 13 PHARMACOLOGY OF MAP KINASES
CHAPTER 14 SMALL G PROTEINS
CHAPTER 15 INTEGRATION IN INTRACELLULAR TRANSDUCTION OF RECEPTOR SIGNALS
CHAPTER 16 LIGAND-GATED ION CHANNELS
CHAPTER 17 G-PROTEIN-COUPLED RECEPTORS
CHAPTER 18 GROWTH FACTOR RECEPTORS
CHAPTER 19 CYTOKINE RECEPTORS
CHAPTER 20 ADHESION MOLECULE RECEPTORS
CHAPTER 21 SOLUBLE CYTOKINE RECEPTORS AND MONOCLONAL ANTIBODIES IN PATHOPHYSIOLOGY AND THERAPY
CHAPTER 22 PHARMACOLOGY OF TRANSCRIPTION
CHAPTER 23 PHARMACOGENETICS AND PERSONALIZED THERAPY
CHAPTER 24 INTRACELLULAR RECEPTORS
CHAPTER 25 RNA MOLECULE AS A DRUG: FROM RNA INTERFERENCE TO APTAMERS
CHAPTER 26 REGENERATIVE MEDICINE AND GENE THERAPY
CHAPTER 27 ION CHANNELS
CHAPTER 28 MEMBRANE TRANSPORTERS
CHAPTER 29 NEUROTRANSMITTER TRANSPORTERS
CHAPTER 30 INTRACELLULAR PROTEOLYSIS
CHAPTER 31 EXTRACELLULAR PROTEOLYSIS
CHAPTER 32 CELL CYCLE AND CELL DEATH
CHAPTER 33 MECHANISMS OF ACTION OF ANTITUMOR DRUGS
CHAPTER 34 MITOCHONDRIA, OXIDATIVE STRESS, AND CELL DAMAGE: PHARMACOLOGICAL PERSPECTIVES
CHAPTER 35 PHARMACOLOGICAL CONTROL OF LIPID SYNTHESIS
CHAPTER 36 GLUCOSE TRANSPORT AND PHARMACOLOGICAL CONTROL OF GLUCOSE METABOLISM
CHAPTER 37 PHARMACOLOGICAL REGULATION OF SYNAPTIC FUNCTION
CHAPTER 38 CATECHOLAMINERGIC TRANSMISSION
CHAPTER 39 CHOLINERGIC TRANSMISSION
CHAPTER 40 THE SEROTONERGIC TRANSMISSION
CHAPTER 41 HISTAMINERGIC TRANSMISSION
CHAPTER 42 GABAergic TRANSMISSION
CHAPTER 43 GLUTAMATE-MEDIATED NEUROTRANSMISSION
CHAPTER 44 PURINERGIC TRANSMISSION
CHAPTER 45 NEUROPEPTIDES
CHAPTER 46 THE OPIOID SYSTEM
CHAPTER 47 THE ENDOCANNABINOID SYSTEM
CHAPTER 48 PHARMACOLOGY OF NITRIC OXIDE
CHAPTER 49 ARACHIDONIC ACID METABOLISM
CHAPTER 50 PHARMACOLOGICAL MODULATION OF THE IMMUNE SYSTEM
CHAPTER 51 MECHANISM OF ACTION OF ANTI-INFECTIVE DRUGS
CHAPTER 52 INTRODUCTION TO TOXICOLOGY
CHAPTER 53 DRUG INTERACTIONS
CHAPTER 54 PRECLINICAL RESEARCH AND DEVELOPMENT OF NEW DRUGS
CHAPTER 55 ROLE OF DRUG METABOLISM AND PHARMACOKINETICS IN DRUG DEVELOPMENT
CHAPTER 56 CLINICAL DEVELOPMENT OF A NEW DRUG AND METHODOLOGY OF DRUG TRIALS

قیمت : 6000 تومان
لینک کوتاه : https://bookbaz.ir/?p=32734
نویسنده : Francesco Clementi , Guido Fumagalli
ناشر : Wiley; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 786
(ISBN) شابک : 1118768574
قیمت کتاب درآمازون : $122.47
حجم فایل : 55 MB

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