دانلود کتاب مبانی منطقی برای ترجمه بالینی در درمان سکته مغزی
Rational Basis for Clinical Translation in Stroke Therapy, 1ed
Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy.
Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients.
The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures.
Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.
About the Author
Giuseppe Micieli is director of the Department of Emergency Neurology at the IRCCS “C. Mondino” Foundation in Pavia, Italy, as well as adjunct professor at the University of Pavia. He received his degree in medicine and surgery from the University of Pavia and holds specialization degrees in neurology and clinical pharmacology. He is former director of the Laboratory of Vegetative Physiopathology, the Headache Centre, and the Sub-intensive Unit of Cerebrovascular Diseases at the IRCCS “C. Mondino” Foundation. He is also the former leader of the Emergency Neurology and Stroke Unit of the Humanitas Clinical Institute in Rozzano, Milan. Dr. Micieli has published more than 170 peer-reviewed articles and held numerous leadership positions including coordinating roles for the Stroke Unit Network and the Italian Stroke Forum.
Chapter 1: Stroke Units, Regional Systems of Emergency Stroke Care, and Telestroke Networks
Chapter 2: Overview of Endovascular Treatment and Revascularization Strategies in Acute Ischemic Stroke
Chapter 3: Benefits and Harms of Pharmacological Thrombolysis
Chapter 4: Mechanical Revascularization Strategies for Stroke Treatment
Chapter 5: Risk Factors and Restroke Prevention
Chapter 6: Genomics for the Advancement of Clinical Translation in Stroke
Chapter 7: Acute Stroke Imaging and Beyond
Chapter 8: Imaging the Penumbra : CTP or Perfusion–Diffusion MRI Mismatch?
Chapter 9: Predictors of Hemorrhagic Transformation of Ischemic Stroke after Thrombolysis
Chapter 10: Imaging Approaches to Map the Penumbra in Preclinical Stroke Models
Chapter 11: Trial Design and Reporting Standards for Acute Intravascular Cerebral Thrombolysis
Chapter 12: Analysis and Interpretation of Outcome Measures in Stroke Clinical Trials
Chapter 13: Evaluation of Interventions in Stroke : The Cochrane Stroke Group Experience
Chapter 14: Neuroprotective Therapy : Failure and Future for Clinical Application
Chapter 15: Stroke Model Guidelines and STAIR Recommendations for Preclinical Stroke Studies
Chapter 16: Animal Models of t–PA-Induced Hemorrhagic Transformation
Chapter 17: Assessment of Sensorimotor Symptoms in Rodents after Experimental Brain Ischemia
Chapter 18: Glutamate and Stroke : From NMDA to mGlu Receptors and Beyond
Chapter ۱۹: Therapeutic Hypothermia for Acute Stroke
Chapter 20: Drug-Induced Hypothermia in Stroke : Current Status and New Therapeutic Approaches
Chapter 21: Immune Response in Cerebral Ischemia : Role of TLRs
Chapter 22: Polarization of Macrophages/Microglia toward an M2 Phenotype as a Therapeutic Strategy for Stroke Treatment
Chapter 23: Minocycline Repurposing for Acute Cerebral Hemorrhage
Chapter 24: NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning
Chapter 25: Cell-Based Therapies for Stroke
Chapter 26: The contribution of Neuroplasticity to Recovery after Stroke
Chapter 27: Stroke Rehabilitation Care : Management and Procedures
Chapter 28: Focal Treatment of Stroke-Related Spasticity in the Rehabilitation Setting : Clinical Exploitation of Botulinum Toxin
Chapter 29: Use of Antidepressants as Adjunctive Therapy to Improve Recovery after Ischemic Stroke
لینک کوتاه : https://bookbaz.ir/?p=117653
نویسنده : Giuseppe Micieli , Diana Amantea
ناشر : CRC Press; 1 edition
سال انتشار : 2015
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 528
(ISBN) شابک : 1466594977
قیمت کتاب درآمازون : $170.84
حجم فایل : 45 MB