Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.
Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.
About the Author
Marianne Martic is a senior assistant at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of the Swiss Federal Institute of Technolgy (ETH) and the University of Zurich (UZH). She joined the institution after obtaining her degree at the radiopharmaceutical institute of ETH Z?rich, where she has worked on animal experimental protocols in the field of positron emission tomography (PET). Her current research is focused on the systematic reviewing and meta-analysis of preclinical animal experiments.
August Schubiger is a senior fellow at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of ETH and UZH. He has been full Professor of Radiopharmacy at the Institute of Pharmaceutical Sciences at ETH Zurich and headed the Center for Radiopharmaceutical Science of the ETH, the Paul Scherrer Institute (PSI) and at the Clinic and Polyclinic for Nuclear Medicine at the UZH until 2010. He is currently involved in the project ‘Drug development – significance and predictive value of animal testing’.
Chapter 1 Introduction
Chapter 2 Ethical Aspects of the Use of Animals in Translational Research
Chapter 3 Study Design
Chapter 4 Improving External Validity of Experimental Animal Data
Chapter 5 Howto End Selective Reporting in Animal Research
Chapter 6 A Comprehensive Overview of Mouse Models in Oncology
Chapter 7 Mouse Models of Advanced Spontaneous Metastasis for Experimental Therapeutics
Chapter 8 Spontaneous Animal Tumor Models
Chapter 9 Dog Models of Naturally Occurring Cancer
Chapter 10 Improving Preclinical Cancer Models: Lessons from Human and Canine Clinical Trials of Metronomic Chemotherapy
لینک کوتاه : https://bookbaz.ir/?p=56131
نویسنده : Marianne I. Martic-Kehl
ناشر : Wiley-VCH; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 275
(ISBN) شابک : 3527339973
قیمت کتاب درآمازون : $110.93
حجم فایل : 4 MB