دانلود کتاب میتوکندری در بیماری های کبدی (استرس اکسیداتیو و بیماری) |
Mitochondria in Liver Disease (Oxidative Stress and Disease), 1ed
“…excellent, well-organized, and timely.”
―Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface
The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.
The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion–fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system.
Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.
About the Author
Derick Han is an assistant professor in the Department of Biopharmaceutical Science at the School of Pharmacy, Keck Graduate Institute, Claremont, California, a member of The Claremont Colleges. He earned his PhD in molecular pharmacology and toxicology from the School of Pharmacy at the University of Southern California. His research focuses on mitochondrial remodeling in the liver caused by metabolic stress, such as alcohol. He is also interested in mitochondrial reprogramming that occurs in cancer cells. He has published more than 70 research publications, reviews, and book chapters.
Neil Kaplowitz, MD, is director of the University of Southern California’s Research Center for Liver Diseases, Los Angeles. He is the Brem Professor of Medicine, the Budnick Chair in Liver Diseases, and the chief of the Division of Gastrointestinal and Liver Diseases. He is also a professor of physiology and biophysics and pharmacology and pharmaceutical sciences at the Keck School of Medicine at the University of Southern California. Dr. Kaplowitz has received a number of honors and distinctions and has served as president of the American Association for the Study of Liver Diseases and as vice chair for research at the American Liver Foundation. He has also been as associate editor of several journals, including Hepatology, Gastroenterology, and the American Journal of Physiology. He has published more than 195 peer-reviewed scientific articles and 150 scholarly reviews and has edited 10 books on liver diseases.
Chapter 1 Metabolism of Superoxide Radicals and Hydrogen Peroxide
Chapter 2 Energy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox Status
Chapter 3 Signal Transduction Pathways That Regulate Mitochondrial Gene Expression
Chapter 4 Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control
Chapter 5 Regulation of Liver Mitochondrial Function by Hydrogen Sulfide
Chapter 6 The Impact of Aging and Calorie Restriction on Liver Mitochondria
Chapter 7 Drug Delivery to Mitochondria: A Promising Approach for the Treatment of Liver Disease
Chapter 8 The Central Role of Mitochondria in Drug-Induced Liver Injury
Chapter 9 The Role of Autophagy and Mitophagy in Liver Diseases
Chapter 10 Mitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver Injury
Chapter 11 Biomarkers of Mitochondrial Damage in the Liver
Chapter 12 Alterations of Mitochondrial DNA in Liver Diseases
Chapter 13 Epigenetic Modifications of Mitochondrial DNA in Liver Disease: Focus on Nonalcoholic Fatty Liver Disease
Chapter 14 The Emerging Role of Mitochondrial Dynamics in Viral Hepatitis
Chapter 15 Mitochondrial Dynamics and Liver Metabolism
Chapter 16 The Role of JNK in Lipotoxicity in the Liver
Chapter 17 Mitochondrial Function, Dysfunction, and Adaptation in the Liver during the Development of Diabetes
Chapter 19 Acid Sphingomyelinase, Mitochondria, and Liver Diseases
Chapter 20 Regulation of Liver Metabolism by Sirtuins: Emerging Roles
لینک کوتاه : https://bookbaz.ir/?p=25121
نویسنده : Derick Han , Neil Kaplowitz
ناشر : CRC Press; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 533
(ISBN) شابک : 1482236974
قیمت کتاب درآمازون : $129.95
حجم فایل : 9 MB