The emergence of nanotherapeutics is attributable to the integration of nanotechnology, recombinant DNA technology, and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs, macromolecular therapeutics, and recombinant vaccine via the common intravascular and extravascular routes.
The book describes the synthetic/chemical engineering methods as well as recombinant, hybridoma, and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics, addressing all relevant human diseases.
A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics, and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations.
About the Author
Dr. Ezharul Hoque Chowdhury is an associate professor and cluster leader of biomedical engineering under the Advanced Engineering Platform at Monash University (Sunway Campus). He obtained his Doctor of Engineering degree in 2003 at Tokyo Tech. Dr. Chowdhury has pioneered the development of pH-sensitive inorganic nanoparticles as smart tools for efficient and targeted intracellular delivery of genetic materials, gene-silencing elements, proteins, and classical anticancer drugs. He is currently applying this smart nanotechnology for the treatment of cancer, particularly breast carcinoma, and cardiovascular diseases, such as diabetes. Dr. Chowdhury holds six Japanese and US patents.
Chapter 1: Emergence of nanotherapeutics : Challenges in classical drug transport versus macromolecular drug design
Chapter 2: The ultimate destinations for delivery and release of nanotherapeutics
Chapter 3: Diversity of bioactive nanopartides from biological, chemical,and physical perspectives
Chapter 4: Fabrication strategies for biofunctional nanoparticles
Chapter 5: Interactions and orientation of therapeutic drugs in the vicinity of nanopartides
Chapter 6: Variable interactions of nanopartides with blood, lymph, and extracellular and intracellular components
Chapter 7: Pharmacokinetics and biodistribution of nanopartides
Chapter 8: Specific roles of nanopartides in various steps of drug transport
Chapter 9: Nanotechnology approaches to modulate transport, release, and bioavailability of classical and emerging therapeutics
Chapter 10: Nanotechnology in the development of innovative treatment strategies
Chapter 11: Nanopartides for therapeutic delivery in animal models of different cancers
Chapter 13: Nanopartides for therapeutic delivery in animal models of other critical human diseases
Chapter 13: Nanomedicine in clinical trials
Chapter 14: Approved and commercialized nanomedicine
Chapter 15: Current safety issues: Biodegradability, reactivity,and clearance
لینک کوتاه : https://bookbaz.ir/?p=42824
نویسنده : Ezharul Hoque Chowdhury
ناشر : CRC Press; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 336
(ISBN) شابک : 1498707513
قیمت کتاب درآمازون : $199.95
حجم فایل : 28 MB