دانلود کتاب ژن درمانی سرطان
Gene Therapy of Cancer, 3ed

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Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive.

Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies.

In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

  • Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches
  • Presents in-depth description of targeting systems and treatment strategies
  • Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Review

“The Third Edition…provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.”–Anticancer Research 34, ۲۰۱۴ “Gene therapy for cancer encompasses reforming genes gone bad, using gene expression to alter the function of both tumor and microenvironment, increasing the sensitivity of cancer cells to killer drugs, and protecting normal cells from such therapies. The studies here cover viral and non-viral vector methodologies: targets and approaches, oncolytic viruses, immunotherapeutics, drug resistance and metabolism gene therapy, cancer therapy imaging vectors, and issues in trail design review and approval.”–Reference & Research Book News, December 2013

Contents

۱ Symptomatic Primary Inguinal Hernia
۲ Recurrent Inguinal Hernia
۳ Incarcerated/Strangulated Inguinal Hernia
۴ Ventral Incisional Hernias
۵ Complex Abdominal Wall Reconstruction
۶ Enterocutaneous Fistula
۷ Infected Ventral Hernia Mesh
۸ Postoperative Dehiscence
۹ Splenectomy for Hematologic Disease
۱۰ Acute Appendicitis
۱۱ Perforated Appendicitis
۱۲ Gynecologic Causes of Lower Abdominal Pain
۱۳ Paraesophageal Hernia
۱۴ Gastroesophageal Refl ux Disease
۱۵ Gastric Cancer
۱۶ Bleeding Gastric Ulcer
۱۷ Bleeding Duodenal Ulcer
۱۸ Perforated Duodenal Ulcer
۱۹ Small Bowel Obstruction
۲۰ Morbid Obesity
۲۱ Gastrointestinal Stromal Tumor
۲۲ Symptomatic Cholelithiasis in Pregnancy
۲۳ Acute Cholecystitis
۲۴ Bile Duct Injury
۲۵ Cholangitis
۲۶ Severe Acute Pancreatitis
۲۷ Incidental Liver Mass
۲۸ Liver Mass in Chronic Liver Disease
۲۹ Metastatic Colorectal Cancer
۳۰ Obstructive Jaundice
۳۱ Incidental Pancreatic Cyst
۳۲ Refractory Pain From Chronic Pancreatitis
۳۳ Symptomatic Pancreatic Pseudocyst
۳۴ Cholecystoduodenal Fistula
۳۵ Lower Gastrointestinal Bleeding
۳۶ Splenic Flexure Colon Cancer
۳۷ Anastomotic Leak After Colectomy
۳۸ Large Bowel Obstruction from Colon Cancer
۳۹ Colonic Vovulus
۴۰ Complicated Diverticulitis
۴۱ Ischemic Colitis
۴۲ Medically Refractory Ulcerative Colitis
۴۳ Crohn’s Disease with Small Bowel Stricture
۴۴ Fulminant Clostridium difficile Colitis
۴۵ Appendiceal Carcinoid Tumor
۴۶ Rectal Cancer
۴۷ Anal Carcinoma
۴۸ Perianal Abscess
۴۹ Thrombosed Hemorrhoids
۵۰ Palpable Breast Mass
۵۱ Suspicious Mammographic Abnormality
۵۲ Ductal Carcinoma In Situ
۵۳ Lobular Carcinoma In Situ
۵۴ Advanced Breast Cancer
۵۵ Inflammatory Breast Cancer
۵۶ Breast Cancer During Pregnancy
۵۷ Breast Reconstruction
۵۸ Palpable Thyroid Nodule
۵۹ Papillary Thyroid Carcinoma
۶۰ Medullary Thyroid Cancer
۶۱ Primary Hyperparathyroidism
۶۲ Persistent Hyperparathyroidism
۶۳ Incidental Adrenal Mass
۶۴ Adrenal Cancer
۶۵ Cortisol-secreting Adrenal Tumor
۶۶ Primary Hyperaldosteronism
۶۷ Pheochromocytoma
۶۸ Pancreatic Neuroendocrine Tumors
۶۹ Gastrinoma
۷۰ Esophageal Cancer
۷۱ Esophageal Perforation
۷۲ Achalasia
۷۳ Solitary Pulmonary Nodule
۷۴ Spontaneous Pneumothorax
۷۵ Pulsatile Abdominal Mass
۷۶ Ruptured Abdominal Aortic Aneurysm
۷۷ Lifestyle-Limiting Claudication
۷۸ Tissue Loss Due to Arterial Insuffi ciency
۷۹ Acute Limb Ischemia
۸۰ Asymptomatic Carotid Stenosis
۸۱ Symptomatic Carotid Stenosis
۸۲ Diabetic Foot Infection
۸۳ Acute Mesenteric Ischemia
۸۴ Chronic Mesenteric Ischemia
۸۵ Deep Venous Thrombosis
۸۶ Need for Hemodialysis Access
۸۷ Emesis in an Infant
۸۸ Malrotation and Midgut Volvulus
۸۹ Neuroblastoma
۹۰ Palpable Abdominal Mass in a Toddler
۹۱ Hepatoblastoma
۹۲ Intussusception
۹۳ Necrotizing Enterocolitis
۹۴ Rectal Bleeding in a Young Child
۹۵ Omphalocele
۹۶ Gastroschisis
۹۷ Tracheoesophageal Fistula
۹۸ Melanoma
۹۹ Melanoma Presenting with Regional Lymph Node Involvement
۱۰۰ Merkel Cell Carcinoma
۱۰۱ Nonmelanoma Skin Cancer
۱۰۲ Necrotizing Soft Tissue Infections
۱۰۳ Extremity Mass (Sarcoma)
۱۰۴ Retroperitoneal Sarcoma
۱۰۵ Penetrating Chest Injury
۱۰۶ Stab Wound to the Neck
۱۰۷ Bums
۱۰۸ Blunt Abdominal Trauma from Motor Vehicle Crash
۱۰۹ Duodenal Injury
۱۱۰ Pelvic Fracture
۱۱۱ Airway Emergency
۱۱۲ Acute Renal Failure
۱۱۳ AdrenalInsuffi ciency
۱۱۴ Acute Respiratory Distress Syndrome (ARDS)
۱۱۵ Ventilator-associated Pneumonia
۱۱۶ Septic Shock
۱۱۷ Abdominal Compartment Syndrome
۱۱۸ Nutritional Support in the Critically III Surgery Patient
۱۱۹ Acute Liver Failure
۱۲۰ Variceal Bleeding and Portal Hypertension
۱۲۱ End-Stage Renal Disease (Renal Transplantation)
۱۲۲ Melanoma of the Head and Neck
۱۲۳ Head and Neck Cancer

قیمت : 6000 تومان
لینک کوتاه : https://bookbaz.ir/?p=33657
نویسنده : Edmund C. Lattime , Stanton L. Gerson MD
ناشر : Academic Press; 3 edition
سال انتشار : 2013
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 668
(ISBN) شابک : 0123942950
قیمت کتاب درآمازون : $191.05
حجم فایل : 37 MB

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