دانلود کتاب ژن و سلول درمانی: مکانیسم درمانی و استراتژی
Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4ed

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The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine

Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fourth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors’ research efforts as well as current technologies, disease targets, and clinical applications.

Divided into four sections, the book covers:

  • Delivery systems and therapeutic strategies
  • Other therapeutic strategies, including technologies that knock down gene expression
  • Gene expression, regulation, and detection
  • Gene and cell therapies, disease targets, clinical trials, and regulatory issues

Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.

Review

“This textbook edited by Nancy Smyth Templeton is exactly what is needed to advance the fields of gene and cell therapy and for general education and further refinement of the technologies. … With over 1,000 pages describing the current gene transfer and vector technologies and the basics of cell therapy and clinical applications, this fourth edition of Gene and Cell Therapy: Therapeutic Mechanisms and Strategies will give an excellent, comprehensive basis to advance gene medicine and cell therapy toward successful future applications in medical practice.”
―From the Foreword by Seppo Ylä-Herttuala, MD, PhD, FESC, Past President, European Society of Gene and Cell Therapy, and Professor of Molecular Medicine, University of Eastern Finland

“The newly updated edition contains additional chapters covering promising gene and cell therapy clinical trials…. The book is also suitable for readers from all backgrounds including students, physicians, scientists, and other individuals interested in understanding the current status of gene and cell therapies and their contribution to the field of medicine.”
SirReadaLot.org, February 2015

About the Author

Nancy Smyth Templeton earned her PhD in molecular biology and biochemistry from Wesleyan University. She underwent postdoctoral training at the National Institutes of Health in the NCI and the NHLBI. She was recently the director of delivery systems at Gradalis/Strike Bio Inc., focusing on targeted delivery of bifunctional shRNA therapeutics to solid tumors by intravenous injections using her robust nanoparticles: bilamellar invaginated vesicles (BIVs). Dr. Templeton has published 62 peer-reviewed papers, presented over 170 seminars, been issued 16 patents, and won several awards.

Contents

Chapter 1: Lentiviral Vectors : Design and Applications
Chapter 2: Adenovirus-Vector-Mediated Gene Delivery : Barriers and Chemical Vector Modifications
Chapter 3: Helper-Dependent Adenoviral Vectors for Gene Therapy
Chapter 4: Adeno-Associated Virus and AAV Vectors for Gene Delivery
Chapter 5: Vaccinia Viral Vectors for Vaccines and Oncolytic Virotherapy
Chapter 6: Oncolytic Measles Virus-Based Delivery Systems
Chapter 7: Alphavirus Vectors in Gene Therapy and Neuroscience
Chapter 8: Oncolytic Viruses for Treatment of Cancer
Chapter 9: Baculovirus : A High-Capacity Vector for Versatile Gene Transfer
Chapter 10: Baculovirus as a Gene Delivery Vector for Bone and Cartilage Tissue Engineering
Chapter 11: Bacteria as Gene Therapy Vectors for Cancer
Chapter 12: Redox-Responsive Polymer-Based Gene Delivery Systems
Chapter 13: Receptor-Targeted Polyplexes for pDNA and siRNA Delivery
Chapter 14: Dendrimers, Dendrigrafts, and Their Conjugations as Delivery Vectors in Gene Therapy
Chapter 15: Gene Electrotransfer
Chapter 16: Magnetofection : Using Magnetic Particles and Magnetic Force to Enhance and Target Nucleic Acid Delivery
Chapter 17: New Advances in Cell-Based Drug and Gene Delivery Systems
Chapter 18: Pressurized Transvenous-Retrograde Extremity Perfusion
Chapter 19: Optimization of Nonviral Gene Therapeutics Using Bilamellar Invaginated Vesicles
Chapter 20: Antisense Oligonucleotide-Based Therapeutics
Chapter 21: Development of RNAi Therapeutics
Chapter 22: Therapeutic Applications of Morpholino Oligonucleotides
Chapter 23: Therapeutic Potential of microRNAs
Chapter 24: Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies
Chapter 25: Deliberate Regulation of Therapeutic Transgenes : Recent Advances in System Development and Uses
Chapter 26: Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems
Chapter 27: Selectable Markers for Gene Therapy
Chapter 28: Pluripotent Stem Cells and Their Therapeutic Applications
Chapter 29: Adult Lung Stem Cells
Chapter 30: Placenta-Derived Cells and Their Therapeutic Applications
Chapter 31: Directing Pluripotent Human Embryonic Stem Cells toward Lineage-Specific Cell Therapy Derivatives for Regenerative Medicine
Chapter 32: Surgical and Translational Aspects of Tissue Engineering
Chapter 33: DNA Vaccines
Chapter 34: Cell and Gene Therapies for Cardiovascular Disease
Chapter 35: Gene Therapy for Hematopoietic Disorders
Chapter 36: Update on Predinical and Clinical Gene Therapy for the Treatment of Cystic Fibrosis
Chapter 37: Gene Therapy for Vision Disorders
Chapter 38: Cell and Gene Therapies for the Treatment of Hearing Disorders
Chapter 39: Molecular Therapy for Type 1 and Type 2 Diabetes
Chapter 40: Alipogene Tiparvovec : Gene Therapy for Familial Lipoprotein Lipase Deficiency
Chapter 41: Gene and Cell Therapies for Muscular Dystrophies
Chapter 42: Gene Therapy Clinical Trials for Muscular Dystrophy
Chapter 43: RNA Interference-Based Gene Therapy Strategies for the Treatment of HIV Infection
Chapter 44: Gene Therapy for the Treatment of Cancer : From Laboratory to Bedside
Chapter 45: Gene Therapy for the Treatment of Lung Cancer
Chapter 46: FANG: bFshRNAifurin and GMCSF DNA-Augmented Autologous Tumor Cell Vaccine : Clinical Results
Chapter 47: Cutaneous Cell- and Gene-Based Therapies for Inherited and Acquired Skin Disorders
Chapter 48: Cell Therapy for the Creation of Cartilage and Related Clinical Trials
Chapter 49: Cell Therapies for the Treatment of Inborn Metabolic Errors
Chapter 50: Cell Therapies for Lung Disease
Chapter 51: Gene Therapy for Neurological Diseases
Chapter 52: Gene Therapy for Alzheimer’s Disease
Chapter 53: Translating Stem Cell Therapy for Alzheimer’s Disease
Chapter 54: Regulatory Aspects of Gene Therapy

رایگان
لینک کوتاه : https://bookbaz.ir/?p=28860
نویسنده : Nancy Smyth Templeton
ناشر : CRC Press; 4 edition
سال انتشار : 2015
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 1330
(ISBN) شابک : 1466571993
قیمت کتاب درآمازون : $250.48
حجم فایل : 33 MB

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