دانلود کتاب کشف دارو بر اساس روش خرد: دروس و چشم انداز
Fragment-based Drug Discovery: Lessons and Outlook, 1ed

Review

Book Description

Contents

۱. The Role of Fragment-based Discovery in Lead Finding
۲. Selecting the Right Targets for Fragment-Based Drug Discovery
۳. Enumeration of Chemical Fragment Space
۴. Ligand Efficiency Metrics and their Use in Fragment Optimizations
۵. Strategies for Fragment Library Design
۶. The Synthesis of Biophysical Methods In Support of Robust Fragment-Based Lead Discovery
۷. Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade
۸. Emerging Technologies for Fragment Screening
۹. Computational Methods to Support Fragment-based Drug Discovery
۱۰. Making FBDD Work in Academia
۱۱. Site-Directed Fragment Discovery for Allostery
۱۲. Fragment Screening in Complex Systems
۱۳. Protein-Templated Fragment Ligation Methods: Emerging Technologies in Fragment-Based Drug Discovery
۱۴. BACE Inhibitors
۱۵. Epigenetics and Fragment-Based Drug Discovery
۱۶. Discovery of Inhibitors of Protein-Protein Interactions Using Fragment-Based Methods
۱۷. Fragment-Based Discovery of Inhibitors of Lactate Dehydrogenase A
۱۸. FBDD Applications to Kinase Drug blunting
۱۹. An Integrated Approach for Fragment-Based Lead Discovery: Virtual, NMRr and Fligh-Throughput Screening Combined with Structure-Guided Design. Application to the Aspartyl Protease Renin,