دانلود کتاب کشف دارو بر اساس روش خرد: دروس و چشم انداز
Fragment-based Drug Discovery: Lessons and Outlook, 1ed

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Review

You can read a review of this book at Practical Fragments:

practicalfragments.blogspot.com/2016/02/fragment-based-drug-discovery-lessons.html

Book Description

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. This book will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in drug discovery techniques. –This text refers to an alternate Hardcover edition.

۱. The Role of Fragment-based Discovery in Lead Finding
۲. Selecting the Right Targets for Fragment-Based Drug Discovery
۳. Enumeration of Chemical Fragment Space
۴. Ligand Efficiency Metrics and their Use in Fragment Optimizations
۵. Strategies for Fragment Library Design
۶. The Synthesis of Biophysical Methods In Support of Robust Fragment-Based Lead Discovery
۷. Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade
۸. Emerging Technologies for Fragment Screening
۹. Computational Methods to Support Fragment-based Drug Discovery
۱۰. Making FBDD Work in Academia
۱۱. Site-Directed Fragment Discovery for Allostery
۱۲. Fragment Screening in Complex Systems
۱۳. Protein-Templated Fragment Ligation Methods: Emerging Technologies in Fragment-Based Drug Discovery
۱۴. BACE Inhibitors
۱۵. Epigenetics and Fragment-Based Drug Discovery
۱۶. Discovery of Inhibitors of Protein-Protein Interactions Using Fragment-Based Methods
۱۷. Fragment-Based Discovery of Inhibitors of Lactate Dehydrogenase A
۱۸. FBDD Applications to Kinase Drug blunting
۱۹. An Integrated Approach for Fragment-Based Lead Discovery: Virtual, NMRr and Fligh-Throughput Screening Combined with Structure-Guided Design. Application to the Aspartyl Protease Renin,

قیمت : 3000 تومان

لینک کوتاه : https://bookbaz.ir/?p=52173
نویسنده : Daniel A. Erlanson
ناشر : Wiley-VCH; 1 edition
سال انتشار : 2016
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 528
(ISBN) شابک : 352733775X
قیمت کتاب درآمازون : $154.26
حجم فایل : 13 MB

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دانلود کتاب کشف دارو بر اساس روش خرد: دروس و چشم اندازFragment-based Drug Discovery: Lessons and Outlook, 1ed

Review

Book Description

Contents

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دانلود کتاب کشف دارو بر اساس روش خرد: دروس و چشم انداز
Fragment-based Drug Discovery: Lessons and Outlook, 1ed