دانلود کتاب کلیه سلدین و گیبیش: فیزیولوژی و پاتوفیزیولوژی
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, 5ed

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A classic nephrology reference for over 25years, Seldin and Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch’s The Kidney is your number one source for information.

  • Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in ۸۵ completely revised chapters and 10 new chapters
  • Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation
  • Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions

Review

“This is a useful resource for both clinical and research nephrologists…it…provides an interesting read if a thorough understanding of a physiological or pathophysiological process affecting the kidney is needed. I would definitely recommend this book to anyone in the nephrology community, whether clinical or research oriented.” Rating: 3 Stars –Doody.com, April 2014

“Ninety-five chapters are arranged across the two volumes under four broad themes: epithelial and nonepithelial transport and regulation; structural and functional organization of the kidney; fluid and electrolyte regulation and dysregulation; and pathophysiology of renal disease.” –Reference and Research Book News, August 2013

Praise for the Previous Edition: “This is an excellent in-depth compilation of all aspects of renal physiology in health and disease, presented in well-balanced in chapters with high-quality figures and ample references…This book clearly represents an excellent, useful, usable, and (in view of recent rapid scientific progress) needed update of the previous edition and will have a prominent place on my bookshelf as well as those of many others in the field.” – 4 Stars! –Doody’s

About the Author

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.

Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology.

Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology.

Contents

۱ Epithelial Cell Structure and Polarity
۲ Mechanisms of Ion Transport across Cell Membranes
۳ Renal Ion-Translocating ATPases
۴ Mechanisms of Water Transport Across Cell Membranes and Epithelia
۵ Cell Volume Control
۶ Solute Transport, Energy Consumption,and Production in the Kidney
۷ Electrophysiological Analysis of Transepithelial Transport
۸ Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
۹ Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular Walls
۱۰ External Balance of Electrolytes and Acids and Alkali
۱۱ Renal Cilia Structure, Function, and Physiology
۱۲ Intercellular Junctions
۱۳ Principles of Cell Signaling
۱۴ Scaffolding Proteins in Transport Regulation
۱۵ The Renin-Angiotensin System
۱۶ Neural Control of Renal Function
۱۷ Eicosanoids and Renal Function
۱۸ Extracellular Nucleotides and Renal Function
۱۹ Paracrine Regulation of Renal Function by Dopamine
۲۰ Structural Organization of the Mammalian Kidney
۲۱ Biophysical Basis of Glomerular Filtration
۲۲ Glomerular Cell Biology
۲۳ Function of the Juxtaglomerular Apparatus: Control of Glomerular Fiemodynamics and Renin Secretion
۲۴ Renal Cortical and Medullary Microcirculations: Structure and Function
۲۵ Molecular and Cellular Mechanisms of Kidney Development
۲۶ Molecular and Cellular Mechanisms of Glomerular Capillary Development
۲۷ Postnatal Renal Development
۲۸ Renal Hyperplasia and Flypertrophy
۲۹ Stem Cells and Generation of New Cells in the Adult Kidney
۳۰ Epithelial Na+ Channels
۳۱ Anion Channels
۳۲ Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
۳۳ Sodium and Chloride Transport: Proximal Nephron
۳۴ Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
۳۵ Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
۳۶ Inherited Disorders of Renal Salt Flomeostasis: Insiohts from Molecular Genetics Studies
۳۷ Natriuretic Hormones
۳۸ Pathophysiology of Sodium Retention and Wastage
۳۹ Physiology and Pathophysiology of Hypertension
۴۰ Physiology and Pathophysiology of Diuretic Action
۴۱ Aquaporin Water Channels in Mammalian Kidney
۴۲ Thirst and Vasopressin
۴۳ The Urine Concentrating Mechanism and Urea Transporters
۴۴ Hyponatremia
۴۵ Hypernatremic States
۴۶ Polyuria and Diabetes Insipidus
۴۷ The Molecular Biology of Renal K+ Channels
۴۸ Extrarenal Potassium Metabolism
۴۹ Regulation of K+ Excretion
۵۰ Physiopathology of Potassium Deficiency
۵۱ Clinical Disorders of Hyperkalemia
۵۲ Control of Intracellular pH
۵۳ SLC4 Sodium-Driven Bicarbonate Transporters
۵۴ The SLC4 Anion Exchanger Gene Family
۵۵ Cellular Mechanisms of Renal Tubular Acidification
۵۶ Chemoreceptors, Breathing and pH
۵۷ Renal Ammonium Ion Production and Excretion
۵۸ Clinical Syndromes of Metabolic Alkalosis
۵۹ Clinical Syndromes of Metabolic Acidosis
۶۰ Respiratory Acid-Base Disorders
۶۱ Mechanisms and Disorders of Magnesium Metabolism
۶۲ Calcium Channels
۶۳ The Calcium-Sensing Receptor
۶۴ Renal Calcium Metabolism
۶۵ The Hormonal Regulation of Calcium Metabolism
۶۶ Disorders of Calcium Metabolism
۶۷ Pathogenesis and Treatment of Nephrolithiasis
۶۸ Proximal Tubular Handling of Phosphate
۶۹ Clinical Disturbances of Phosphate Homeostasis
۷۰ Glucose Reabsorption in The Kidney
۷۱ Kidney Transport of Amino Acids and Oligopeptides,and Aminoacidurias
۷۲ Organic Anion and Cation Transporters in Renal Elimination of Drugs
۷۳ Renal Filtration, Transport,and Metabolism of Albumin and Albuminuria
۷۴ Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders
۷۵ Biomarkers for Assessment of Renal Function During Acute Kidney Injury
۷۶ Pathophysiology of Acute Kidney Injury
۷۷ Ischemic Renal Disease
۷۸ Pathophysiology and Pathogenesis of Diabetic Nephropathy
۷۹ Renal Failure in Cirrhosis
۸۰ Autosomal Dominant Polycystic Kidney Disease
۸۱ Renal Physiology and Disease in Pregnancy
۸۲ Immune and Inflammatory Glomerular Diseases
۸۳ Immunologic Mechanisms of Vasculitis
۸۴ Genetic Abnormalities in Glomerular Function
۸۵ Cellular Mechanisms of Drug Nephrotoxicity
۸۶ Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
۸۷ Role of Proteinuria in the Progression of Renal Disease
۸۸ The Inflammatory Response to Ischemic Acute Renal Injury
۸۹ Catalytic [Labile) Iron in Kidney Disease
۹۰ Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
۹۱ Management of Calcium and Bone Disease in Renal Patients
۹۲ Hematopoiesis and the Kidney
۹۳ Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
۹۴ Homeostasis of Solute and Water by the Transplanted Kidney
۹۵ Renal Disposition of Drugs and Translation to Dosing Strategies

قیمت : 6000 تومان
لینک کوتاه : https://bookbaz.ir/?p=40048
نویسنده : Robert J. Alpern , Michael J. Caplan
ناشر : Academic Press; 5 edition
سال انتشار : 2013
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 3299
(ISBN) شابک : 0123814626
قیمت کتاب درآمازون : $390.00
حجم فایل : 66 MB

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