دانلود کتاب گلوتاتیون (استرس اکسیداتیو و بیماری)
Glutathione (Oxidative Stress and Disease), 1ed

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This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins – a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.

Key selling features:

  • Summarizing the way glutathione is involved in stress responses
  • Compiling the multiple ways glutathione affects inflammatory responses
  • Disclosing how glutathione dampens programmed cell death such as ferroptosis
  • Exploring the enigma of how enzymes accelerate glutathione-dependent processes
  • Discussing how detoxification and redox regulation is mediated by glutathionylation
  • Reviewing the ways glutaredoxins catalyze protein disulfide reduction
  • Highlighting the medical impact of glutathione-related metabolic pathways
  • Illustrating the role thiol metabolism of pathogens might play in drug discovery

About the Author

Leopold Flohé is Professor at the Universidad de la Republica Uruguay in Montevideo, Uruguay. He also Distinguishing Visiting Professor in the Department of Molecular Medicine at the University of Padova in Italy. He has been recognized by PubMed.gov as a Redox Pioneer because has published an article on antioxidant/redox biology, as first author, that has been cited more than 1,000 times, and more than 20 articles have been cited more than 100 times. He obtained the medical doctorate at the Institute of Pharmacology and Toxicology at the University of Tübingen, Germany, in 1968. He held positions in both Academia (Tübingen, Aachen, and Braunschweig, Germany) and industry (Aachen). He is now operating the biotech company MOLISA in Magdeburg, Germany, while teaching as guest professor at the local university.

Contents

Chapter 1 Biosynthesis of Glutathione and Its Regulation
Chapter 2 Renal Glutathione Transport Systems: Roles in Redox Homeostasisr Cytoprotection and Bioactivation
Chapter 3 The Catalytic Mechanism of Glutathione Peroxidases
Chapter 4 GPxl-Dependent Regulatory Processes in Health and Disease
Chapter 5 Glutathione Peroxidase 1 as a Modulator of Insulin Production and Signaling: Implications for Its Dual Role in Diabetes
Chapter 6 GPx2 Role in Physiology and Carcinogenesis
Chapter 7 GPx4: From Prevention of Lipid Peroxidation to Spermatogenesis and Back
Chapter 8 Thiolsr Glutathione, GPx4r and Lipid Metabolism at the Crossroads of Cell Death and Survival
Chapter 9 Peroxiredoxin 6 as Glutathione Peroxidase
Chapter 10 Glutathione Peroxidases and the Thyroid Gland
Chapter 11 Glutathione Transferases: From the Test Tube to the Cell
Chapter 12 Protein S-Glutathionylation and Glutathione S-Transferase P
Chapter 13 The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism
Chapter 14 Nitric Oxide and S-Nitrosoglutathione
Chapter 15 The Catalytic Mechanism of Glutaredoxins
Chapter 16 The Role of Glutaredoxins in the Brain
Chapter 17 Biosynthesis of Polyamine-Glutathione Derivatives in Enterobacteria and Kinetoplastida
Chapter 18 Trypanothione Functions in Kinetoplastida
Chapter 19 Mycothiol, a Low-Molecular-Weight Thiol Drafted for Oxidative Stress Defense Duty
Chapter 20 Biosynthesis and Functions of Bacillithiol in Firmicutes

قیمت : 3000 تومان
لینک کوتاه : https://bookbaz.ir/?p=115296
نویسنده : Leopold Flohe
ناشر : CRC Press; 1 edition
سال انتشار : 2019
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 410
(ISBN) شابک : 0815365322
قیمت کتاب درآمازون : $118.81
حجم فایل : 7 MB

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