دانلود کتاب فیبروز کیستیک هادسون و گدس
Hodson and Geddes’ Cystic Fibrosis 5th Edition

Cystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from across the world. It will be a useful reference for clinicians, including all levels of trainees, across the whole multidisciplinary team, scientists and students.

Contents

۱ Journey from Macromolecular Pathology to Molecular Therapies
۲ Global Epidemiology of CF: High-Income and Low-/Middle-Income Countries (Global Harmonization Registry Countries)
۳ Voices of Patients and Families
۴ Patient Organisations
۵ Molecular Biology of CFTR: From the Gene to the Protein
۶ Biology of the CF Airway Epithelium
۷ The Physiology of Epithelial Ion and Fluid Transport: Beyond CFTR Modulators
۸ Inflammation in Cystic Fibrosis
۹ Model Organisms of Cystic Fibrosis
۱۰ Systems Biology and the New Omics
۱۱ Genotype: Phenotype Correlations
۱۲ Gene Environment Interactions
۱۳ Demographic, Socioeconomic, and Environmental Contributions to Health in Cystic Fibrosis
۱۴ Drug Discovery Platforms for CFTR Modulators
۱۵ CFTR Modulator Drug Discovery and Translation into the Clinic
۱۶ Newborn and Carrier Screening for CF
۱۷ Diagnostic Tests: Sweat Testing, Epithelial Potential Differences and Genetic Testing
۱۸ Immediate Management of the Newly Screened Positive Baby
۱۹ Diagnosis of the Symptomatic Patient
۲۰ Blurred Boundaries: CRMS/CFSPID and CFTR-Related Disorders
۲۱ Respiratory Disease across the Lifecourse
۲۲ Respiratory Effects of the New CFTR Modulators
۲۳ Epidemiology and Microbiology of Cystic Fibrosis Pulmonary Infections
۲۴ New Methods for Detecting and Identifying Bacteria
۲۵ Non-Tuberculous Mycobacterial Infections in Cystic Fibrosis
۲۶ Fungal Diseases in CF
۲۷ Molecular Microbiology of the CF Gut and Lung
۲۸ Pulmonary Exacerbations in Cystic Fibrosis: Epidemiology, Treatment, Outcomes, and Future Research
۲۹ Infection Prevention and Control in Cystic Fibrosis
۳۰ Technology in Cystic Fibrosis Therapies
۳۱ Upper Airway Disease in Cystic Fibrosis
۳۲ Gastrointestinal Disease in CF
۳۳ Cystic Fibrosis Liver Disease
۳۴ Cystic Fibrosis-Related Diabetes
۳۵ Growth in Cystic Fibrosis: Is Chloride Transport the Key?
۳۶ Bone Disease in Cystic Fibrosis
۳۷ Cancer and Cystic Fibrosis
۳۸ Other Cystic Fibrosis-Related Diseases and Complications
۳۹ Extrapulmonary Benefits of the New CFTR Modulator Drugs
۴۰ Sexual Health, Fertility, and Pregnancy in People with Cystic Fibrosis
۴۱ Mental Health Issues in Cystic Fibrosis
۴۲ Adherence and Self-Management in Cystic Fibrosis Care
۴۳ Transplantation
۴۴ Working with Cystic Fibrosis
۴۵ Growing Old with Cystic Fibrosis
۴۶ Imaging of Cystic Fibrosis Lung Disease
۴۷ Lung Function Testing Including Multiple Breath Washout
۴۸ Infant Pulmonary Function Tests
۴۹ Exercise Testing in Cystic Fibrosis
۵۰ Bronchoscopy and Bronchoalveolar Lavage in Cystic Fibrosis
۵۱ Patient-Derived Cell-Based Models for Theratyping and Individual CFTR Modulator Assessment
۵۲ Minimally Invasive Investigations for Biomarkers of Airways Disease
۵۳ Current and Future Interventional Trial Designs to Support the CF Therapeutic Pipeline
۵۴ Gene and RNA-Based Therapies
۵۵ Cystic Fibrosis in Limited Resource Settings
۵۶ Traveling with Cystic Fibrosis
۵۷ Organisation of Cystic Fibrosis Centre Care
۵۸ The Role of the CF Nurse Specialist
۵۹ Physiotherapy
۶۰ The Role of the Dietitian
۶۱ The Role of the Pharmacist as Part of the Multidisciplinary Team Caring for CF Patients
۶۲ The Role of a Psychologist on the Cystic Fibrosis Care Team
۶۳ Adolescent Health and Transition in Cystic Fibrosis
۶۴ Palliative and Supportive Care
۶۵ Using Registries and Databases to Drive Up Quality
۶۶ Digital Transformations within CF Healthcare
۶۷ Personalized Medicine for Cystic Fibrosis in the 21st Century
۶۸ CF Research Priorities for the Future