دانلود کتاب بیماری های نورودنژنتیک: اصول یونیفایینگ
Neurodegenerative Diseases: Unifying Principles, 1ed

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As the global population ages the impact of neurodegenerative disease.s like Alzheimer’s disease and Parkinson’s disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.

Neurodegenerative Disease.s: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

Review

“Age-related neurodegeneration is among the most important, most interesting and most complex areas of science. The field is exploding with new developments, and, thankfully, therapeutic strategies. Drs. Cummings and Pillai have assembled a wonderful book exploring the common features and challenges that link the study of neurodegenerative diseases, including proteinopathy, neuroinflammation, genetics and epigenetics, biomarkers and cognitive/behavioral syndromes, with the laudable aim of facilitating cross-fertilization of ideas that may accelerate therapeutic advance.” –Paul Stephen Aisen, MD, Director, Alzheimer’s Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA

About the Author

Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been featured in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards.

Dr. Jagan A Pillai is a cognitive neurologist at the Lou Ruvo Center for Brain Health, Cleveland Clinic. He trained as a medical doctor at the University of Kerala and obtained a PhD from Northwestern University. His training in neurology was completed at the Albert Einstein College of Medicine and at the University of California San Diego. Dr. Pillai is closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases and in developing diagnostic and treatment strategies against neurodegenerative diseases.

Contents

۱. Neurodegenerative Disease.s: Evolving Unifying Principles
۲. Neurodegenerative Disease.s as Protein Misfolding Disorders
۳. Calcium Hypothesis of Neurodegeneration: The Case of Alzheimer’s Disease and Huntington’s Disease
۴. Neuroinflammation and Neurodegenerative Diseases
۵. Prion Paradigm of Human Neurodegenerative Disease.s Caused by Protein Misfolding
۶. Neuropsychiatric Features Across Neurodegenerative Disease.s
۷. Brain Circuits: Neurodegenerative Disease.s
۸. Fluid Biomarkers Indicative of Neurodegenerative Diseases
۹. Predementia Disorders: Neurodegenerative Disorder Predecessor States as Unifying Clinical Features
۱۰. Genetics of Neurodegenerative Disease.s: Sporadic and Autosomal Dominant Forms
۱۱. An Epigenetics Perspective on Disease.s of the Central Nervous System
۱۲. Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases
۱۳. Cell Culturer iPS Cells and Neurodegenerative Diseases
۱۴. Animal Models of Neurodegenerative Disease.s
۱۵. Metal-Protein Attenuating Compounds in Neurodegenerative Disease.s
۱۶. Disease-Modifying Therapies in Neurodegenerative Disorders
۱۷. Immunotherapy for Neurodegenerative Disorders
۱۸. Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles
۱۹. Conclusions on Neurodegenerative Disorders: Unifying Principles

قیمت : 3000 تومان
لینک کوتاه : https://bookbaz.ir/?p=67128
نویسنده : Jagan A Pillai , Jeffrey L Cummings
ناشر : Oxford University Press; 1 edition
سال انتشار : 2017
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 361
(ISBN) شابک : 0190233567
قیمت کتاب درآمازون : $117.27
حجم فایل : 7 MB

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۳۰۰۰ تـومان – خرید