دانلود کتاب درسی بیماری فون ویلبراند: جنبه های اساسی و بالینی
Textbook of Von Willebrand Disease: Basic and Clinical Aspects 2nd Edition

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder

The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2^nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery.

Many advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF/ADAMTS13 as risk factors of thrombosis.

Edited by a team of experts in VWD and an international team of contributors, Textbook of von Willebrand Disease covers sample topics such as:

• VWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance
• Clinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD
• Pediatric aspects of VWD and of women with VWD
• Management of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates
• Acquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease

Providing complete and accessible coverage of the subject, Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2^nd edition is a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding/clotting disorders.

Contents

۱ Historical perspective on von Willebrand disease
۲ Biosynthesis and organization of von Willebrand factor
۳ Von Willebrand factor structure and function
۴ Regulation of von Willebrand factor expression
۵ Modulation of VWF by ADAMTS13
۶ Assessment of VWF clearance
۷ Classification of VWD
۸ The epidemiology of von Willebrand disease
۹ Clinical aspects of von Willebrand disease: bleeding history
۱۰ Laboratory diagnosis of von Willebrand disease: the phenotype
۱۱ Molecular diagnosis of von Willebrand disease: the genotype
۱۲ Clinical laboratory and molecular markers of type 1 von Willebrand disease and low vonWillebrand factor
۱۳ Clinical and molecular markers of type 1C VWD
۱۴ Clinical and molecular markers of VWD2A
۱۵ Clinical and molecular markers of VWD2B
۱۶ Clinical and molecular markers of type 2M VWD
۱۷ Clinical and molecular markers of VWD2N
۱۸ Clinical laboratory and molecular markers of type 3 von Willebrand disease
۱۹ Pediatric aspects of von Willebrand disease
۲۰ Women with von Willebrand Disease
۲۱ The use of desmopressin in von Willebrand disease
۲۲ Plasma-derived and recombinant VWF concentrates
۲۳ Pathophysiology epidemiology and management of acquired von Willebrand syndrome
۲۴ Cardiovascular causes of AVWS
۲۵ Von Willebrand factor regulation of angiogenesis and vascular integrity: implications forgastrointestinal angiodysplasia
۲۶ Prophylaxis in von Willebrand disease
۲۷ Risk of thrombosis and antithrombotic treatment in von Willebrand disease patients
۲۸ Novel functions for VWF beyond hemostasis