دانلود کتاب اصول تشخیص مولکولی و شخصی پزشکی سرطان
Principles of Molecular Diagnostics and Personalized Cancer Medicine, 1ed

Principles of Molecular Diagnostics and Personalized Cancer Medicine

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Improve your understanding of…

• The basic mechanisms of carcinogenesis—including material on cell proliferation, signal transduction pathways, cancer stem cells, and the interaction between genetics and environmental factors.
  • The most current molecular techniques—including  polymerase chain reaction (PCR) technique, single nucleotide polymorphisms, cancer cytogenomics and epigenetics,  whole-genome assessments, and next- generation sequencing.
• Molecular tests—including molecular screening, minimal residual disease detection, circulating tumor cell tests, molecular tumor staging, and molecular cancer prognosis assessment.
• Imaging and screening technologies—including molecular imaging, genetic tests, biostatistics, and bioinformatics.
• The molecular basis of therapy—including critical molecules as special treatment targets, particularly genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles.
• Molecular diagnostics – including updated molecular diagnostic approaches to common malignancies and role of pathology in targeted cancer management.
• Targeted treatment – including personalized medicine and targeted therapy for commonly occurring malignancies— plus insights on new approaches to targeted drug discovery and the future of molecular oncology!

Contents

۱ Cell Proliferation and Apoptosis
۲ Cancer Stem Cells
۳ Cell Signal Transduction
۴ Oncogenes
۵ Tumor Suppressor Genes
۶ Viruses and Human Cancers
۷ Introduction to Molecular Techniques and Instrumentation
۸ Transcriptome Analysis
۹ Immunohistochemistry
۱۰ Cancer Genomic Sequencing
۱۱ Mass Spectrometry: Principlesand Applications in Cancer Diagnosis and Management
۱۲ Cancer Proteomics
۱۳ Morphoproteomics
۱۴ Flow Cytometry
۱۵ Cancer Cytogenomics
۱۶ DNA Hypermethylation in Cancer
۱۷ Single Nucleotide Polymorphisms
۱۸ Overview of Molecular Tests and Personalized Cancer Medicine
۱۹ Molecular Screeningr GeneticCounselingr and Canee[Prevention: Lynch Syndrome as a Model
۲۰ Molecular Imaging and CancerManagement: PET and MRAgentsfor Molecular Imaging of Cancer Metabolism
۲۱ Detection and Molecular Monitoring of MinimalResidual Diseases in Myeloid Neoplasms
۲۲ Molecular Assessment of Cancer Prognosis
۲۳ Quality Control, Assurance,and Standardization of Molecular Diagnostics
۲۴ Biostatistics and Bioinformatics
۲۵ In Vitro Companion Diagnostic
۲۶ Molecular Biology and Pathology of Lung Cancer: Genotype-Morphology Correlation
۲۷ Molecular Diagnostics of Breast Cancer
۲۸ Molecular Diagnostics of Colorectal Cancer
۲۹ Molecular Diagnostics of Esophageal and Gastric Cancers
۳۰ Molecular Biology of Prostate Cancer: Practical Considerations for Diagnosis and Prognosis
۳۱ Molecular Diagnostics of Hepatocellular Careinoma
۳۲ Molecular Diagnostics of Pancreatic Cancer
۳۳ Molecular Diagnostics of Head and Neck Cancer
۳۴ Immunohistochemical and Molecular Diagnosis of Melanoma
۳۵ Molecular Diagnostics of Hematopoietic Neoplasms
۳۶ Molecular Diagnostics of Lymphomas
۳۷ Molecular Diagnostics of Gynecologic Neoplasms
۳۸ Molecular Diagnostics of Bladder and Kidney Cancers
۳۹ Molecular Diagnosis of Soft Tissue Sarcomas
۴۰ Molecular Diagnosis of Glioma
۴۱ Molecular Diagnostics of Pediatric Neoplasms
۴۲ Molecular Diagnostics of Metastatic Malignancies
۴۳ DNA Repair and Cancer Therapeutics
۴۴ Monoclonal Antibodies for the Treatment of Cancer
۴۵ Vaccines and Cancer Therapy
۴۶ Cancer Gene Therapy: Nucleic Adds as Therapeutic Agents
۴۷ Anti-angiogenesis Therapy of Cancer
۴۸ MicroRNAs and Cancer Therapeutics
۴۹ Molecular Basis of Cancer Radiation Treatment
۵۰ Nanotechnology and Cancer Therapy
۵۱ New Approaches to Integration of Personalized Medicine in Early Cancer Drug Development
۵۲ Personalized Medicine and Targeted Therapy of Lung Cancer
۵۳ Personalized Medicine and Targeted Therapy of Breast Cancer
۵۴ Personalized Medicine and Targeted Therapy for Colorectal Cancer
۵۵ Personalized Medicine and Targeted Therapy of Esophageal Cancer
۵۶ Personalized Medicine and Targeted Therapy of Gastric Cancer
۵۷ Personalized Medicine and Targeted Therapy for Prostate Cancer
۵۸ Personalized Medicine and Targeted Therapy of Hepatocellular Carcinoma
۵۹ Personalized Medicine and Targeted Therapy of Pancreatic Cancer: Current Status and Proposed Strategies
۶۰ Personalized Medicine and Targeted Therapy of Neuroendocrine Neoplasms
۶۱ Personalized Medicine and Targeted Therapy of Head and Neck Cancer
۶۲ Personalized Medicine and Targeted Therapy for Melanoma
۶۳ Personalized Medicine and Targeted Therapy of Leukemia
۶۴ Personalized Medicine and Targeted Therapy of Gynecologic Cancers
۶۵ Personalized Medicine and Targeted Therapy of Renal Cell Carcinoma
۶۶ Personalized Medicine and Targeted Therapy of Gliomas
۶۷ Personalized Medicine and Targeted Therapy for Osteosarcoma
۶۸ Molecular Basis of Chemoradiotherapy and High-Precision Radiotherapy
۶۹ New Approaches to Personalized Medicine and Targeted Drug Discovery
۷۰ The Future of Molecular Diagnostics in Oncology