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Stem Cell Therapeutics for Cancer, 1ed

A single-source reference on the hot topic of stem cell therapeutics for cancer

This work offers a thorough, cohesive look at the state of the art of stem cell therapeutics for cancer, with an emphasis on the unique application of mesenchymal stem cells (MSC) and MSC-like cells as gene-delivery agents in cancer treatment. Edited by a leader in the field, the book brings together a wealth of information from this growing area of research, highlighting topics critical to the success of future therapies, including stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics.

Organized in sections according to disease types, the chapters explore the engineering of specific stem cell types with the protein of interest as well as results from studies of animal models and early-phase clinical trials. The use of cutting-edge molecular imaging techniques for a variety of tumor types is also integrated into the text. Coverage includes:

• An overview of stem cell types and their fate in models of cancer
• Stem cell monotherapy in brain cancers, lung cancers, breast cancers, and other malignancies
• The use of stem cells in combination with other therapies
• Diagnostic tracking of both stem cells and therapeutic molecules in cancer treatments
• Possible adverse effects of MSC on tumors, including details on tumor-initiating cells in certain tumor types

Clear, concise, and up to date, Stem Cell Therapeutics for Cancer is a must-have resource for scientists and clinicians in stem cell research, cancer therapies, novel drug development, and molecular imaging, and for anyone wishing to learn about the unprecedented potential of stem cell therapeutics for various cancer types.

Contents

Chapter 1 Stem Cell Sources and Their Potential for Cancer Therapeutics
Chapter 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration
Chapter 3 Tumor Tropism of Mesenchymal Stem Cells
Chapter 4 Stem Cell-Mediated TRAIL Therapy for Highly Aggressive Brain Tumors
Chapter 5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors
Chapter 6 Role of Naive Cord Blood Stem Cells in Glioma Therapy
Chapter 7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors
Chapter 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy
Chapter 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer
Chapter 10 Mesenchymal Stromal Cells as Effective Tumor Antigen-Presenting Cells in Cancer Therapeutics
Chapter 11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment
Chapter 12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy
Chapter 13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities
Chapter 14 Primed Mesenchymal Stromal Cells for Cancer Therapy
Chapter 15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy
Chapter 16 Stem Cell-Based Combination Therapies for Cancer: Systemic Delivery of a PIBK/mTOR Inhibitor (PI-103] and Stem Cell-Mediated Delivery of TRAIL in Brain Tumors
Chapter 17 The Efficacy of Clinically Approved Agents with Stem Cell-Delivered Therapeutics for Cancer Therapy
Chapter 18 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer
Chapter 19 Multifunctional Molecules for Interrogating Stem Cell-Based Therapeutics
Chapter 20 Tracking Cancer-Targeted MSC with PET Imaging