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Dental Enamel Formation to Destruction, 1ed

This account of enamel begins with the formation of enamel via epithelio-mesenchymal interactions, and continues through its emergence into the mouth and its final destruction by the most common disease in the western world, dental caries.

Dental enamel’s claim to fame, if one can use such a phrase, lies in several unique aspects of its formation, structure, and pathology. It is the most highly mineralized of all the skeletal tissues, presenting the most extreme example of the calcification process seen, to a lesser extent, in bone, dentine, and cementum. Unlike these latter tissues, it is ectodermally derived and its constituent crystals of calcium hydroxyapatite are far larger and more perfectly formed than those of its mesenchymal counterparts. In this respect, as well as being a worthy subject of investigation for its own sake, it is an ideal model for the study of the fundamental aspects of the elaboration and processing of extracellular matrices and the calcification process itself.

In addition, enamel is the subject of the most common disease experienced by man — dental caries: a disease process which uniquely has generated an entire profession. Despite a reduction in its incidence of as much as 50% in recent times, the disease is still widespread and in some developing countries is now on the increase. Another remarkable feature of enamel is that it is associated with perhaps the most effective public health measure of all — fluoridation. It is the interaction between enamel and the fluoride ion from either the diet or topically applied dental health products which is at the heart of this success story.

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Contents

Chapter 1 Differentiation of Ameloblasts and its Regulation by Epithelial-Mesenchymal Interactions
Chapter 2 The Cell Biology of Amelogenesis
Chapter 3 Molecular Biology of the Amelogenin Gene
Chapter 4 Biochemistry of the Developing Enamel Matrix
Chapter 5 Role of the Extracellular Matrix in Enamel Development
Chapter 6 Structure of Developing Enamel
Chapter 7 Structure of Mature Enamel
Chapter 8 Chemistry of Mature Enamel
Chapter 9 Hereditary Defects of Enamel
Chapter 10 The Chemistry of Dental Caries
Chapter 11 Dental Fluorosis