دانلود کتاب مرزها در تحقیقات دارویی بالینی – ایدز
Frontiers in Clinical Drug Research – HIV, Vol-3, 1ed

Human immunodeficiency virus (HIV) is responsible for AIDS (Acquired Immune Deficiency Syndrome), due to which the immune system of the body is badly affected and natural defense mechanisms become compromised. This opens the way for many infectious diseases to attack simultaneously. The treatment of HIV has been directed to decrease mortality and increase the number of clinically secured patients. Volume 1 of the book series “Frontiers in Clinical Drug Research – HIV” presents important recent developments in the form of cutting edge reviews written by eminent professionals.

Highly active antiretroviral therapy (HAART) uses multiple drugs that can act on special viral targets which in turn maintain the functions of the immune system. Chapter 1 by Phillips and Svard summarizes the current status in terms of development of drugs to target various stages of the disease and to refine the use of current drugs.

Viral suppression reduces the function and replication of a virus. It also decreases the amount of virus in the blood. Successful antiretroviral therapy is being used for sustained HIV viral suppression and immunological recuperation in HIV infected patients. Casseb and Arruda in Chapter 2 discuss the advances in the field of antiretroviral agents (ART) that focus on two main types of inhibitors, integrase inhibitors and entry inhibitors.

Contents

۱. Human Papillomavirus in HIV Positive People
۲. Allosteric Integrase Inhibitors
۳. HAART: A Boon to Mankind
۴. The Current Progress and Challenge in the Development of Entry Inhibitors of HIV-1
۵. Prospects of Reverse Transcriptase Inhibitors
۶. HIV-1Integrase Inhibitors: Targets and Clinical Application
۷. The Current Progress and Challenge in the Development of Protease Inhibitors of HIV-1
۸. Blocking HIV-1Replication via Targeting the Tat-mediated Transcriptional Machinery