دانلود کتاب NMR در علم گلیکو و گلیکوتکنولوژی
NMR in Glycoscience and Glycotechnology, 1ed

This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration.

In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Book Description

Focusing on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics which will have significant impact on the development of therapeutic agents eg vaccines, this volume is timely and useful not only for NMR specialists but also for a broader scientific community. The precise analysis of glycosylation patterns in humans can be used in therapies of utmost importance. However, the complexity and heterogeneity of dynamic glycan structures often discouraged researchers from actively challenging and addressing this important issue. Written by leading experts in the field, this book is an important contribution to the literature in this area for a wide spectrum of readers.

Contents

Chapter 1 Intramolecular Hydrogen Bonding in Glycans in Aqueous Solution
Chapter 2 NMR Spin-Couplings in Saccharides: Relationships Between Structure, Conformation and the Magnitudes of JHH, JCH and JCC Values
Chapter 3 Insights into Carbohydrate Recognition by 3D Structure Determination of Protein–Carbohydrate Complexes Using NMR
Chapter 4 Paramagnetic, RDC and RCSA Constraints in the Structural Analysis of Glycans
Chapter 5 Lanthanide-Chelating Carbohydrate Conjugates to Detect Carbohydrate–Protein Interactions
Chapter 6 NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids
Chapter 7 NMR Analysis of Glycosyltransferases
Chapter 8 Stable Isotope Labeling of Glycoproteins for NMR Study
Chapter 9 Quantifying Carbohydrate Motions Through Solution Measurements: Applications to Immunoglobulin G Fc
Chapter 10 Analysis of Glycosaminoglycans by 15N-NMR Spectroscopy
Chapter 11 NMR Studies of Protein–Glycosaminoglycan Interactions
Chapter 12 Solid-State NMR Analysis of Mannose Recognition by Pradimicin A
Chapter 13 Structure and Dynamics of Polysaccharides in Plant Cell Walls from Solid-State NMR
Chapter 14 New Methods for the Analysis of Heterogeneous Polysaccharides – Lessons Learned from the Heparin Crisis
Chapter 15 NMR Chemical Shif Predictions and Structural Elucidation of Oligo- and Polysaccharides by the Computer Program CASPER
Chapter 16 NMR Databases for Plant Cell Wall Biopolymers
Chapter 17 Polysaccharides as Major Carbon Sources in Environmental Biodiversity

قیمت : 3500 تومان

لینک کوتاه : https://bookbaz.ir/?p=72214
نویسنده : Koichi Kato ,‎ Thomas Peters
ناشر : Royal Society of Chemistry; Gld edition
سال انتشار : 2017
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 418
(ISBN) شابک : 1782623108
قیمت کتاب درآمازون : $216.76
حجم فایل : 13 MB

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