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Principles of Pharmacology, 4ed

This new edition was recognized as a highly commended title by the British Medical Association at the ۲۰۱۷ BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.

The Fourth Edition features:

• Comprehensive updates to all chapters, including recently approved drugs
• Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
• A new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
• Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters
• Hundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

Contents

۱ Drug–Receptor Interactions
۲ Pharmacodynamics
۳ Pharmacokinetics
۴ Drug Metabolism
۵ Drug Transporters
۶ Drug Toxicity
۷ Pharmacogenomics
۸ Principles of Cellular Excitability
۹ Principles of Nervous System Physiology and Pharmacology
۱۰ Cholinergic Pharmacology
۱۱ Adrenergic Pharmacology
۱۲ Local Anesthetic Pharmacology
۱۳ Pharmacology of GABAergic and Glutamatergic Neurotransmission
۱۴ Pharmacology of Dopaminergic Neurotransmission
۱۵ Pharmacology of Serotonergic and Central Adrenergic Neurotransmission
۱۶ Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System
۱۷ General Anesthetic Pharmacology
۱۸ Pharmacology of Analgesia
۱۹ Pharmacology of Drugs of Abuse
۲۰ Pharmacology of Cholesterol and Lipoprotein Metabolism
۲۱ Pharmacology o Volume Regulation
۲۲ Pharmacology o Vascular Tone
۲۳ Pharmacology o Hemostasis and Thrombosis
۲۴ Pharmacology o Cardiac Rhythm
۲۵ Pharmacology o Cardiac Contractility
۲۶ Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure
۲۷ Pharmacology o the Hypothalamus and Pituitary Gland
۲۸ Pharmacology o the Thyroid Gland
۲۹ Pharmacology o the Adrenal Cortex
۳۰ Pharmacology o Reproduction
۳۱ Pharmacology o the Endocrine Pancreas and Glucose Homeostasis
۳۲ Pharmacology o Bone Mineral Homeostasis
۳۳ Principles o Antimicrobial and Antineoplastic Pharmacology
۳۴ Pharmacology o Bacterial In ections: DNA Replication, Transcription, and Translation
۳۵ Pharmacology o Bacterial and Mycobacterial In ections: Cell Wall Synthesis
۳۶ Pharmacology o Fungal In ections
۳۷ Pharmacology o Parasitic In ections
۳۸ Pharmacology o Viral In ections
۳۹ Pharmacology o Cancer: Genome Synthesis, Stability, and Maintenance
۴۰ Pharmacology o Cancer: Signal Transduction
۴۱ Principles o Combination Chemotherapy
۴۲ Principles o Inf ammation and the Immune System
۴۳ Pharmacology o Eicosanoids
۴۴ Histamine Pharmacology
۴۵ Pharmacology o Hematopoiesis and Immunomodulation
۴۶ Pharmacology o Immunosuppression
۴۷ Integrative Inf ammation Pharmacology: Peptic Ulcer Disease
۴۸ Integrative Inf ammation Pharmacology: Asthma
۴۹ Integrative Inf ammation Pharmacology: Gout
۵۰ Environmental Toxicology
۵۱ Drug Discovery and Preclinical Development
۵۲ Clinical Drug Evaluation and Regulatory Approval
۵۳ Systematic Detection o Adverse Drug Events
۵۴ Protein Therapeutics
۵۵ Drug Delivery Modalities