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Disordered Pharmaceutical Materials, 1ed

A one-stop resource for researchers and developers, this handbook and ready reference provides detailed, but not overloaded information — presenting the topic without unnecessarily complex formalism.
As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, preparation and characterization techniques as well as molecular modeling approaches for the target-oriented development of drug delivery systems based on amorphous solids. Chapters on the challenges of using these materials in large-scale processes in the pharmaceutical industry and on patenting issues round off the book.
For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

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Contents

Chapter 1 Some Facets of Molecular Disorder in Crystalline and Amorphous Pharmaceuticals
Chapter 2 Influence of Disorder on Dissolution
Chapter 3 Crystal Imperfections in Molecular Crystals: Physical and Chemical Consequences
Chapter 4 Observation and Characterization of Crystal Defects in Pharmaceutical Solids
Chapter 5 “Enantiomeric Disorder” Pharmaceutically Oriented
Chapter 6 Conformational Disorder and Atropisomerism in Pharmaceutical Compounds
Chapter 7 Tautomerism in Drug Delivery
Chapter 8 Disorders in Pharmaceutical Polymers
Chapter 9 Polymer Gels, Hydrogels,and Scaffolds-An Overview
Chapter 10 Use of the Pair Distribution Function Analysis in the Context of Pharmaceutical Materials
Chapter 11 Application of Broadband Dielectric Spectroscopy to Study Molecular Mobility in Pharmaceutical Systems
Chapter 12 Raman Spectroscopy in Disordered Molecular Compounds: Application to Pharmaceuticals
Chapter 13 Study of Disordered Materials by Terahertz Spectroscopy
Chapter 14 Study of Disorder by Solid-State NMR Spectroscopy
Chapter 15 Processing-Induced Disorder in Pharmaceutical Materials
Chapter 16 Patenting of Inventions Relating to Solid Forms, with Special Considerations on Disordered Forms