دانلود کتاب درمان هدفمند در پژوهش‌ های کاربردی‌ سازی سرطانی
Targeted Therapy in Translational Cancer Research, 1ed

In the last decade, emergent technologies have enhanced our understanding of genomic, transcriptional, proteomic, epigenetic, and immune mechanisms in carcinogenesis. This improved understanding has enabled the development of targeted cancer therapies and personalized management, and transformed conventional treatment paradigms. It has provided the framework for the discovery of new targets, for validation of novel agents, for combination therapies predicated upon scientific rationale, and for clinical trials that have already markedly improved the prognosis and outcome of patients with cancer.

Over 37 chapters this volume of Translational Oncology series, Targeted Therapy in Translational Cancer Research:

• Introduces the cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer
• Provides a comprehensive overview of recent developments in our understanding of tumor biology and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy
• Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine
• Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

We are on the threshold of translating discoveries in cancer biology into unprecedented durable responses and improved clinical outcomes in the majority of patients with cancer. In this unique time in history, the discovery of novel therapeutic approaches targeting the molecular basis of cancer will allow for implementation of precision medicine, with the promise of potentially curative, well tolerated, therapies. Targeted Therapy in Translational Cancer Research was written to increase the awareness and access of basic and clinical researchers, caregivers, and patients alike to cutting-edge “bench to bedside and back” breakthroughs, which have transformed the diagnosis, prognosis, and treatment of cancer.

The expert editor team and contributing authors provide an insightful overview to the novel therapeutic approaches targeting the molecular basis of cancer and allowing for the growth of precision medicine. This title is an essential resource for clinical and research oncologists and trainees, pharmacologic research and development professionals, biomedical scientists, and allied oncology professionals.

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Contents

۱ Toward Personalized Therapy for Cancer
۲ Combining Targeted Therapies
۳ Principles of Targeted Immunotherapy
۴ Cancer Stem Cell Principles
۵ The Tumor Microenvironment as a Target for Therapeutic Intervention
۶ The Role of Angiogenesis in Cancer
۷ Epigenetics and Epigenetic Therapy of Cancer
۸ The Role of microRNAs in Cancer
۹ AcuteMyeloidLeukemia
۱۰ Targeted and Functional Imaging
۱۱ Targeted Therapies in Chronic Myeloid Leukemia
۱۲ Targeted Therapy for Acute Lymphoblastic Leukemia
۱۳ Chronic Lymphocytic Leukemia
۱۴ Multiple Myeloma
۱۵ The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas
۱۶ Targeted Therapy in Myelodysplastic Syndromes
۱۷ Lymphoma and Targeted Therapies
۱۸ Targeted Therapy in Solid Tumors: Brain
۱۹ Targeted Therapy for Breast Cancer
۲۰ Targeted Therapy in Solid Tumors: Colorectal Cancer
۲۱ Endometrial Cancer
۲۲ Targeted Therapy in Solid Tumors: Head and Neck
۲۳ Targeted Therapy in Solid Tumors: Lung Cancer
۲۴ Targeted Therapy in Melanoma
۲۵ Ovarian Cancer
۲۶ Molecular Therapeutics: Pancreatic Cancer
۲۷ Targeted Therapies for Pediatric Solid Tumors
۲۸ Prostate Cancer
۲۹ Renal Cell Carcinoma and Targeted Therapy
۳۰ Targeted Therapy in Solid Tumors: Sarcomas
۳۱ RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities
۳۲ The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies
۳۳ Current Status and Future Direction of PARP Inhibition in Cancer Therapy
۳۴ Targeting the c-Met Kinase
۳۵ KIT Kinase
۳۶ TP53
۳۷ Future Perspectives