دانلود کتاب راهنمای سیستم های دارورسانی هدفمند ریوی
Handbook of Lung Targeted Drug Delivery Systems, 1ed

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals.

Key Features:

• • Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research.

• • Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases

• • Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications

• Examines specific formulations targeted to pulmonary systems

Contents

۱. Introduction to Lung Physiology from a Drug Delivery Perspective
۲. Introduction to Pharmacology of the Lung from a Drug Delivery Perspective
۳. Mechanism and Ways of Pulmonary Drug Administration
۴. Transepithelial Route of Drug Delivery through the Pulmonary System
۵. Understanding the Pharmacokinetics and Pharmacodynamics of Lung and Lung Drug Delivery
۶. Chronic Lung Diseases: Treatment Challengesr and Solutions
۷. Understanding of Lung Diseases with a Focus on Applications of Nano-particulate Drug Delivery Systems
۸. Model for Pharmaceutical aerosol transport through stenosis airway
۹. Design of Efficient Dry Powder Inhalers
۱۰. In Vivo Animal Models for Lung Targeted Drug Delivery Systems
۱۱. Advances in In Silico Study of Generic Orally Inhaled Drug Products
۱۲. Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model
۱۳. Pulmonary Drug Delivery: The Role of Polymeric Nanoparticles
۱۴. Polymeric Nanoparticle-Based Drug-Gene Delivery for Lung Cancer
۱۵. Inhalable Polymeric Nano-particulate Powders for Respiratory Delivery
۱۶. Recent Trends in Applications of Nano-Drug Delivery Systems
۱۷. Nanocarrier Systems for Lung Drug Delivery
۱۸. Nanomedicine for the Management of Pulmonary Disorders
۱۹. Recent Approaches in Dendrimer-Based Pulmonary Drug Delivery
۲۰. Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier
۲۱. Solid Lipid Nanoparticle-Based Drug Delivery for Lung Cancer
۲۲. Lipid-Based Pulmonary Delivery System: A Review and Future Considerations of Formulation Strategies and Limitations
۲۳. Respirable Controlled Release Polymeric Colloidal Nanoparticles
۲۴. Lung Clearance Kinetics of Liposomes and Solid Lipid Nanoparticles
۲۵. Solid Lipid Nanoparticles for Sustained Pulmonary Delivery of Herbal Drugs for Lung Delivery: Preparation, Characterization and In Vivo Evaluation
۲۶. Improved Solid Lipid Nano-formulations for Pulmonary Delivery of Paclitaxel for Lung Cancer Therapy
۲۷. Anti-angiogenic Therapy for Lung Cancer: Focus on Bioassay Development in a Quest for Anti-VEGF Drugs
۲۸. Emerging Applications of Nanoparticles for Lung Cancer Diagnosis and Therapy
۲۹. Metallic Nanoparticles: Technology Overview and Drug Delivery Applications in Lung Cancer
۳۰. Modeling of Pharmaceutical Aerosol Transport in the Targeted Region of Human Lung Airways Due to External Magnetic Field
۳۱. Phytochemicals and Biogenic Metallic Nanoparticles as Anti-cancer Agents in Lung Cancer
۳۲. Pulmonary Applications and Toxicity of Engineered Metallic Nanoparticles
۳۳. Anti-cancer Activity of Eco-friendly Gold Nanoparticles against Lung and Liver Cancer Cells
۳۴. Sub-chronic Inhalational Toxicity Studies for Gold Nanoparticles
۳۵. Single-Use Dry Powder Inhalers for Pulmonary Drug Delivery
۳۶. Lung Delivery of Nicotine for Smoking Cessation
۳۷. Formulation and Characterization of Dry Powder Inhalers for Pulmonary Drug Delivery
۳۸. Devices for Dry Powder Drug Delivery to the Lung
۳۹. Numerical Modeling of Agglomeration and De-agglomeration in Dry Powder Inhalers
۴۰. Oronasal and Tracheostomy Delivery of Soft Mist and Pressurized Metered-Dose Inhalers with Valved Holding Chamber
۴۱. Modeling for Biopharmaceutical Performance in Lung Drug Discovery
۴۲. Regulatory Consideration for Approval of Generic Inhalation Drug Products in the USr EU, Brazil,. China, and India
۴۳. Regulatory Perspectives and Concerns Related to Nanoparticle-Based Lung Delivery
۴۴. Clinical Controversies of Pediatric Aerosol Therapy
۴۵. Drug Delivery Using Aerosols: Challenges and Advances in Neonatal Pediatric Subgroup
۴۶. Safety and Toxicological Concerns Related to Nanoparticle-Based Lung Delivery
۴۷. Nanoparticle-Based Lung Drug Delivery: A Clinical Perspective
۴۸. European Perspective on Orally Inhaled Products: In Vitro Requirements for a Biowaiver