دانلود کتاب سرطان استخوان: سرطانهای استخوان اولیه و متاستاتهای استخوانی
Bone Cancer: Primary Bone Cancers and Bone Metastases, 2ed

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials.

Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work
Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system
Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases
Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Review

“…a comprehensive description of bone tumors from basic to clinical aspects by the most recent data available…specifically useful to medical students and scientists, health professionals, researchers and teachers working in the osteo-articular field.” —Anticancer Research

“Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic.” —Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King’s College London, United Kingdom

“Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists.” —Roland Baron, Professor, Harvard Medical School, Boston MA, USA

۱. Epidemiology of primary bone tumors and economical aspects of bone metastases
۲. Tumor–bone interactions: there is no place like bone
۳. Stem cell niches in the bone–bone marrow organ and their significance for hematopoieticand non-hematopoietic cancer
۴. Deregulation of osteoblast differentiation in primary bone cancers
۵. Contribution of osteoclasts to the bone–tumor niche
۶. Involvement of osteocytes in cancer bone niche
۷. Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis
۸. Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma
۹. Macrophages and pathophysiology of bone cancers
۱۰. Cytokines and bone cancers
۱۱. Technical aspects: how do we best prepare bone samples for proper histological analysis?
۱۲. Bone remodeling markers and bone cancer
۱۳. Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas
۱۴. Homeobox genes from the Dlx family and bone cancers
۱۵. MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors
۱۶. Hypoxia and angiogenesis: from primary tumor to bone metastasis
۱۷. Modeling osteosarcoma: in vitro and in vivo approaches
۱۸. Stemness markers of osteosarcoma
۱۹. Molecular pathology of osteosarcoma
۲۰. Gene and proteomic profiling of osteosarcoma
۲۱. Ewing sarcoma family of tumors
۲۲. Biology of Ewing sarcoma
۲۳. Osteoclast-rich lesions of bone: a clinical and molecular overview
۲۴. Markers for bone sarcomas
۲۵. Margins and bone tumors – what are we talking about?
۲۶. Cytogenetics of bone tumors
۲۷. Genetic aspects of bone tumors
۲۸. Cytogenetic and molecular genetic alterations in bone tumors
۲۹. Genetics of giant cell tumors of bone
۳۰. Mammalian models of bone sarcomas
۳۱. Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos
۳۲. Imaging of bone sarcomas
۳۳. New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials
۳۴. Therapeutic approaches for bone sarcomas
۳۵. Chondrosarcoma of bone: diagnosis and therapy
۳۶. Apoptosis and drug resistance in malignant bone tumors
۳۷. Giant cell tumors of bone
۳۸. EMT process in bone metastasis
۳۹. Histopathology of skeletal metastases
۴۰. Disseminated tumor cells in bone marrow of cancer patients
۴۱. MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton
۴۲. Myeloma and osteoclast relationship
۴۳. In vivo models used in studies of bone metastases
۴۴. Interventional radiologic techniques in management of bone tumors
۴۵. Diagnosis of bone metastases in urological malignancies – an update
۴۶. Pre-clinical molecular imaging of “the seed and the soil” in bone metastasis
۴۷. Mechanisms and management of bone cancer pain
۴۸. Bone cancer: current opinion in palliative care
۴۹. Involvement of sympathetic nerves in bone metastasis
۵۰. Pain control with palliative radiotherapy in patients with bone metastases
۵۱. Cellular and molecular actions of bisphosphonates
۵۲. The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal
۵۳. Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC)
۵۴. A multitargeted approach to treating bone metastases
۵۵. Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions
۵۶. Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases
۵۷. Bone metastases – current status of bone-targeted treatments
۵۸. Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases

قیمت : 7000 تومان

لینک کوتاه : https://bookbaz.ir/?p=116079
نویسنده : Dominique Heymann
ناشر : Academic Press; 2 edition
سال انتشار : 2015
زبان کتاب : انگلیسی
نوع فایل : PDF
تعداد صفحات : 679
(ISBN) شابک : 9780124167216
قیمت کتاب درآمازون : $132.31
حجم فایل : 45 MB

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دانلود کتاب سرطان استخوان: سرطانهای استخوان اولیه و متاستاتهای استخوانیBone Cancer: Primary Bone Cancers and Bone Metastases, 2ed

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دانلود کتاب سرطان استخوان: سرطانهای استخوان اولیه و متاستاتهای استخوانی
Bone Cancer: Primary Bone Cancers and Bone Metastases, 2ed