دانلود کتاب فناوری نانو و دارو (۲ جلدی)
Nanotechnology and Drug Delivery, 2-Vol, 1ed

Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation.

Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described in volume one, volume two, Nano-Engineering Strategies and Nanomedicines against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting. Particular aspects of nanomedicine engineering and in vivo fate associated with the routing of drug administration are given special attention. In addition, an up-to-date view is presented on the use of nanomedicines against severe diseases, such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, and metabolic diseases. The chapters analyze the key factors that need to be controlled to achieve the optimum therapeutic effect. Attention is further given to gene delivery and the recent concept of nanotheranosis.

Contents

Volume 1: Nanoplatforms in Drug Delivery

CHAPTER 1: Key Aspects in Nanotechnology and Drug Delivery
CHAPTER 2: Drug Delivery and Release from Polymeric Nanomaterials
CHAPTER 3: Nano-Sized Polymeric Drug Carrier Systems
CHAPTER 4: Reversible Cross-Linked Polymeric Nanoplatform in Drug Delivery
CHAPTER 5: Cyclodextrins in Drug Delivery
CHAPTER 6: Drug Delivery Systems Based on Tyrosine-derived Nanospheres [TyroSpheres }
CHAPTER 7: Carbon Nanotubes for Drug Delivery Applications
CHAPTER 6: Metallic Nanoparticulate Drug Delivery Systems
CHAPTER 9: Porous Silica Nanoparticles for Drug Delivery and Controlled Release
CHAPTER 10: Iron Oxides in Drug Delivery
CHAPTER 11: Nanoengineered Magnetic Field-Induced Targeted Drug Delivery System with StimulFResponsive Release

Volume 2: Nano-Engineering Strategies and Nanomedicines against Severe Diseases

Chapter 1: Emerging Technologies of Polymers for Nanomedicine Applications
Chapter 2: Nanotechnology for Oral Drug Delivery and Targeting
Chapter 3: Nanoparticulate Systems for Dental Drug Delivery
Chapter 4: Nanotechnology for Topical and Transdermal Drug Delivery and Targeting
Chapter S: Nanotechnology for Pulmonary and Nasal Drug Delivery
Chapter 6: Lipid Nanoplatforms for Pulmonary Drug Delivery
Chapter 7: Nanotechnology for Ocular and Otic Drug Delivery and Targeting
Chapter 8: Nanotechnology for Vaginal Drug Delivery and Targeting
Chapter 9: Potential Nanocarriers for Brain Drug Delivery
Chapter 10: Nanomaterials and Cancer Therapy
Chapter 11: Nanomedicine in Cardiovascular Disease
Chapter 12: Nano[Neuro)Medicinal Interventions for Neurodegenerative Disorders
Chapter 13: Nanomedicines against Infectious Diseases
Chapter 14: Nanomedicines against Chronic Inflammatory Diseases
Chapter 15: Nanomedicine Biopharmaceuticals for Metabolic Diseases
Chapter 16: Nanotechnology in Gene Knockdown and miRNA Replacement In Vivio
Chapter 17: Nanotheranostics