دانلود کتاب فیوژن ژنها و سرطان
Fusion Genes and Cancer, 1ed

Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of ‘fusion genes’ seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date.

Contents

۱. Cancer — An Overview and Molecular Alterations in Cancer
۲. Basic Concepts of Fusion Genes and Their Classification
۳. Techniques to Identify Novel Fusion Genes and to Detect Known Fusion Genes
۴. The Receptor Tyrosine Kinase ALK — Its Fusion Partners and Their Implication in Various Cancers
۵. Role of BCR-ABL Fusion Kinase in the Development of Leukemia
۶. BRD4-NUT Fusion Oncoprotein and Its Significance in the Initiation and Progression of NUT Midline Carcinoma
۷. Importance of CBFB-MYH11 — A Chimeric Transcriptional Regulator in Leukemia
۸. Rearrangements Involving ETS Family of Genes and Their Role in Different Cancers
۹. Translocation of FET Family Members with Various Partner Genes and Their Role in Cancer Development
۱۰. Translocations of FGF and FGFR Proteins and Their Effect in Cancer
۱۱. IG/MYC and Its Implication in Cancer
۱۲. Chimeric RAF Kinases in the Development of Cancer
۱۳. Mucoepidermoid Carcinoma (MEC) and Associated MAML2 Fusion Genes
۱۴. Mixed Lineage Leukemia/AF9 Fusion and Associated Leukemia
۱۵. MYB-NFIB Fusion Gene — Hallmark of Adenoid Cystic Carcinoma (ACC)
۱۶. Translocations Involving PAX Family Genes and Their Effect in Cancer
۱۷. Retinoic Acid Receptor Alpha (RARα) Fusion Genes in Leukemia
۱۸. RET/PTC Translocations and Thyroid Malignancies
۱۹. RUNX1 or AML1 Fusion Genes in Leukemia and Other Cancers
۲۰. Recently Discovered Fusion Genes and Their Implications in Cancer
۲۱. Targeting Fusion Genes for Cancer Therapy