دانلود کتاب متاستاز سرطان و سلول/نیچ بنیادی سرطان
Cancer Metastasis and Cancer Stem Cell/Niche, 1ed

A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Cancer Stem Cell/Niche explains the invasiveness and metastasis of cancer cells in the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

A malignant tumor is an actively growing tissue, composed of cells derived from a single cell that has undergone abnormal irreversible differentiation. These cells have two fundamental qualities: invasion and metastasis that induce the risk of cancer. Interestingly, recent researchers suggest that a malignant tumor is originated from cancer stem cells (CSC) accompanied with the niches. In this eBook, I would like to ask how the invasion and metastasis of cancer cells are explained by CSC theory and/or niche theory. The major points are as follows.

Contents

۱. Fundamental Relationships Between Cancer Stem Cells, the Cancer Stem Cell Niche and Metastasis
۲. Regulation of Cell Surface Glycan Expression in Cancer Stem Cells
۳. Tumor Endothelial Cells and Cancer Progression
۴. Metastatic Cancer Stem Cell Niche and the Toll-like Receptor 4 (TLR4)-mediated Premetastatic Microenvironment
۵. Cancer Stem Cell and Clinical Cancer Metastasis in Surgical Oncology