دانلود کتاب اپتوژنتیک
Optogenetics, 1ed

Discovered little more than a decade ago, optogenetics – a revolutionary technique combining genetic and optical methods to observe and control the function of neurons – is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson’s disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

Review

Contents

۱. Introduction to Optogenetics: From Neuronal Function to Mapping and Disease Biology
۲. Uncovering Key Neurons for Manipulation in Mammals
۳. From Connectome to Function: Using Optogenetics to Shed Light on the Caenorhabditis elegans Nervous System
۴. From Synapse to Behavior: Optogenetic Tools for the Investigation of the Caenorhabditis elegans Nervous System
۵. Using Optogenetics In Vivo to Stimulate Regeneration in Xenopus laevis
۶. Sodium and Engineered Potassium Light-Driven Pumps
۷. Methods for Simultaneous Electrophysiology and Optogenetics In Vivo
۸. Application of an Optogenetic Technique to a Study of Activity-dependent Axon Growth in the Developing Cortex
۹. Development of an Optogenetic Tool to Regulate Protein Stability In Vivo
۱۰. Photoactivatable Nucleotide Cyclases for Synthetic Photobiology Applications
۱۱. Bioluminescence Activation of Light-sensing Molecules
۱۲. Optogenetics for Neurological Disorders: What Is the Path to the Clinic?
۱۳. Optogenetic Control of Astroglia
۱۴. Optogenetics for Neurohormones and Neuropeptides: Focus on Oxytocin
۱۵. Optogenetic Approaches to Investigating Brain Circuits
۱۶. Optogenetic Mapping of Neuronal Connections and their Plasticity
۱۷. Optogenetics to Study Reward Learning and Addiction
۱۸. Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disorders
۱۹. Optogenetics Research in Behavioral Neuroscience: Insights into the Brain Basis of Reward Learning and Goal-directed Behavior
۲۰. Toward an Optogenetic Therapy for Epilepsy
۲۱. Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Function
۲۲. Optogenetics in Treating Retinal Disease
۲۳. Optogenetics for Vision Recovery: From Traditional to Designer Optogenetic Tools
۲۴. A Promise of Vision Restoration
۲۵. Holographic Optical Neural Interfacing with Retinal Neurons
۲۶. Strategies for Restoring Vision by Transducing a Channelrhodopsin Gene into Retinal Ganglion Cells
۲۷. Optogenetic Dissection of a Top-down Prefrontal to Hippocampus Memory Circuit
۲۸. Optogenetic Dissection of Sleep–Wake Control: Evidence for a Thalamic Control of Sleep Architecture
۲۹. Optogenetics and Auditory Implants
۳۰. Optogenetic Stimulation for Cochlear Prosthetics
۳۱. The Role of Amino Acids in Neurodegenerative and Addictive Diseases
۳۲. Optogenetics in Deep Brain Stimulation: Ethical Considerations