دانلود کتاب داروهای ضد پیری: از تحقیقات پایه به تمرین بالینی
Anti-aging Drugs: From Basic Research to Clinical Practice, 1ed

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies.

This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field.
A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Contents

Chapter 1 Anti-Aging Drugs: Where are We and Where are We Going
Chapter 2 Aging: Natural or Disease A View from Medical Textbooks
Chapter 3 The Search for the “Anti-Aging Pill”: A Critical Viewpoint
Chapter 4 Testing of Geroprotectors in Experiments on Cell Cultures: Pros and Cons
Chapter 5 Pharmacogenomics and Epigenomics of Age-Related Neurodegenerative Disorders: Strategies for Drug Development
Chapter 6 Nanotechnology in Anti-Aging: Nutraceutical Delivery and Related Applications
Chapter 7 Hormetins as Drugs for Healthy Aging
Chapter 8 Antioxidant Therapy of Aging: From Free Radical Chemistry to Systems Theory of Reliability
Chapter 9 Mitochondria-Targeted Rechargeable Antioxidants as Potential Anti-Aging Drugs
Chapter 10 Mimetics of Caloric Restriction
Chapter 11 Allosteric SIRT1 Activators as Putative Anti-Aging Drugs
Chapter 12 Therapeutic Potential of Sirtuin Inhibitors in Cancer
Chapter 13 Lifespan-Extending Effect of Resveratrol and Other Phytochemicals
Chapter 14 Extending Lifespan by Inhibiting the Mechanistic Target of Rapamycin (mTOR)
Chapter 15 mTOR, Aging and Cancer: Prospects for Pharmacological Interventions
Chapter 16 Anti-Aging Action of PPARs: Potential Therapeutic Targets
Chapter 17 Antidiabetic Biguanides as Anti-Aging Drugs
Chapter 18 S-Adenosylmethionine Metabolism: A Promising Avenue in Anti-Aging Medicine
Chapter 19 Melatonin as a Geroprotector: Healthy Aging vs. Extension of Lifespan
Chapter 20 Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span
Chapter 21 HDAC Inhibitors: A New Avenue in Anti-Aging Medicine
Chapter 22 Human Life Extension: Opportunities, Challenges, and Implications for Public Health Policy