دانلود کتاب راهبردهای درمان های آنتی سنس اولیگونوکلئوتید
Delivery Strategies for Antisense Oligonucleotide Therapeutics, 1ed

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Contents

Chapter 1 Disrupting the flow of genetic information with antisense oligodeoxynudeotides: Research and Therapeutic Applications
Chapter 2 Cellular Delivery of Ribozymes
Chapter 3 Improved structural design and cellular uptake of triplex-forming oligonucleotides
Chapter 4 Pharmacokinetics and delivery of oligonucleotides to the brain
Chapter 5 In vivo pharmacokinetics of oligonucleotides following administration by different routes
Chapter 6 Nudease-resistant DNA therapeutics
Chapter 7 Self-stabilized oligonucleotides as novel antisense agents
Chapter 8 Circular oligonucleotides as potential modulators of gene expression
Chapter 9 Peptide nucleic acids as antisense therapeutic agents
Chapter 10 Stabilized RNA analogs for antisense and ribozyme applications
Chapter 11 Uptake and localization of phosphodiester and chimeric oligodeoxynudeotides in normal and leukemic primary cells
Chapter 12 Oligonucleotide transport across membranes and into cells: effects of chemical modifications
Chapter 13 Liposomes as a delivery system for antisense and ribozyme compounds
Chapter 14 Intracellular delivery of oligonucleotides with cationic liposomes
Chapter 15 The delivery of oligonucleotides using pH-sensitive liposomes
Chapter 16 Enhancing endosomal exit of nucleic acids using pH-sensitive viral fusion peptides
Chapter 17 Targeted delivery of anti-hepatitis B antisense oligonucleotides
Chapter 18 Design, synthesis, and cellular delivery of antibody-antisense oligonucleotide conjugates for cancer therapy