دانلود کتاب شیمی دارویی: اصول و تمرین
The Handbook of Medicinal Chemistry: Principles and Practice

Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery.

Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.

A free iPad app has been created in collaboration with the editors of the book. The Medicinal Chemistry Toolkit provides a suite of resources to support the day to day work of a medicinal chemist. Search for “Medicinal Chemistry Toolkit.”

Review

Contents

Chapter 1 Physicochemical Properties and Compound Quality
Chapter 2 Parallel Synthesis and Library Design
Chapter 3 Useful Computational Chemistry Tools for Medicinal Chemistry
Chapter 4 Structure-Based Design for Medicinal Chemists
Chapter 5 Fragment Based Lead Discovery
Chapter 6 Quantitative Structure–Activity Relationships
Chapter 7 Drug Metabolism
Chapter 8 Prediction of Human Pharmacokinetics, Exposure and Therapeutic Dose in
Chapter 9 Molecular Biology for Medicinal Chemists
Chapter 10 Assays
Chapter 11 In Vitro Biology: Measuring Pharmacological Activity
Chapter 12 Animal Models: Practical Use and Considerations
Chapter 13 Bioinformatics for Medicinal Chemistry
Chapter 14 Translational Science
Chapter 15 Discovery Toxicology In Lead Optimisation
Chapter 16 Toxicology and Drug Development
Chapter 17 Patents for Medicines
Chapter 18 The Modern Drug Discovery Process
Chapter 19 Target Validation for Medicinal Chemists
Chapter 20 Lead Generation
Chapter 21 Lead Optimisation: What You Should Know!
Chapter 22 Pharmaceutical Properties—the Importance of Solid Form Selection
Chapter 23 The Chemical Development and Medicinal Chemistry Interface
Chapter 24 Project Management
Chapter 25 Clinical Drug Development
Chapter 26 Aleglitazar: A Case Study
Chapter 27 Lessons Learned From the Discovery and Development of
Chapter 28 ‘‘Daring to be Different’’: The Discovery of Ticagrelor