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Animal Models for Human Cancer, 1ed

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.

Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

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Contents

Chapter 1 Introduction
Chapter 2 Ethical Aspects of the Use of Animals in Translational Research
Chapter 3 Study Design
Chapter 4 Improving External Validity of Experimental Animal Data
Chapter 5 Howto End Selective Reporting in Animal Research
Chapter 6 A Comprehensive Overview of Mouse Models in Oncology
Chapter 7 Mouse Models of Advanced Spontaneous Metastasis for Experimental Therapeutics
Chapter 8 Spontaneous Animal Tumor Models
Chapter 9 Dog Models of Naturally Occurring Cancer
Chapter 10 Improving Preclinical Cancer Models: Lessons from Human and Canine Clinical Trials of Metronomic Chemotherapy