دانلود کتاب پاتولوژی بافت نرم، یک موضوع کلینیک های پاتولوژی جراحی
Soft Tissue Pathology, An Issue of Surgical Pathology Clinics, 1ed

This issue of Surgical Pathology Clinics, guest edited by Dr. Elizabeth G. Demicco, focuses on Soft Tissue Pathology. Topics include, but are not limited to, Prognostic and therapeutic biomarkers in sarcoma, Mesenchymal tumors with SMARC deficiency, Mesenchymal tumors with EWSR1-rearrangements, Update on fatty tumors, Pleomorphic sarcomas, Update on peripheral nerve sheath tumors, Beyond leiomyosarcoma – other mesenchymal tumors of the gynecologic tract, Non-Ewing small round cell tumors, Update on myogenic sarcomas, Radiation-associated Sarcomas, Practical application of cytology, and Update on molecular diagnostics in vascular tumors.

Soft tissue sarcomas are a diverse and diagnostically challenging group of malignancies that may arise at any anatomic site. Classification of these tumors relies on morphology (e.g. spindle cell, round cell, epithelioid, or pleomorphic), line of differentiation (e.g. smooth muscle, vascular, adipocytic, skeletal muscle, nerve sheath, or unrelated to normal tissue lineages), and genomic features (specific gene-fusion, mutation driven, complex karyotype), and the differential diagnosis may vary depending on the tumor site, patient age, and sex. These classification systems overlap and interact in complex ways, such that tumors of myogenic differentiation, for instance, may be classified as mutation associated (a subset of spindle cell/sclerosing rhabdomyosarcoma), translocation driven (alveolar rhabdomyosarcoma, another subset of spindle cell/sclerosing rhabdomyosarcoma), or complex karyotype (pleomorphic rhabdomyosarcoma). Moreover, some sarcomas can behave differently based on site of origin (uterine vs soft tissue leiomyosarcoma), while multiple diverse tumors share EWSR1-related gene fusions as common driver event and may display overlapping morphologic features, while showing very different clinical behaviors (e.g., soft tissue myoepithelioma and extraskeletal myxoid chondrosarcoma).

Contents

۱. Update on Peripheral Nerve Sheath Tumors
۲. Update on Lipomatous Tumors with Emphasis on Emerging Entitiesr Unusual Anatomic Sites, and Variant Histologic Patterns
۳. The Molecular Diagnostics of Vascular Neoplasms
۴. Update on Myogenic Sarcomas
۵. Pleomorphic Sarcomas
۶. Radiation-Associated Sarcomas
۷. SWI/SNF Complex-Deficient Soft Tissue Neoplasms
۸. Mesenchymal Tumors with EWSR1 Gene Rearrangements
۹. Important Recently Characterized Non-Ewing Small Round Cell Tumors
۱۰. Prognostication in Mesenchymal Tumors
۱۱. Practical Application of Cytology and Core Biopsy in the Diagnosis of Mesenchymal Tumors