دانلود کتاب ایمونولوژی بالینی: اصول و عمل
Clinical Immunology: Principles and Practice, 6ed

Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.

• Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine.
• Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma.
• Provides new genetics content focused on data applications.
• Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more.
• Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics.
• Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles.
• Summarizes promising research and development anticipated over the next 5–۱۰ years with “On the Horizon” boxes and discussions of translational research.

Contents

۱. The Human Immune Response
۲. Organization of the Immune System
۳. Innate Immunity
۴. Antigen Receptor Genes, Gene Products, and Co-Receptors
۵. The Major Histocompatibility Complex
۶. Antigens and Antigen Presentation
۷. B-Cell Development and Differentiation
۸. Immunoglobulin Function
۹. T-Cell Development
۱۰. T-Cell Activation and Tolerance
۱۱. Helper T-Cell Subsets and Control of the Inflammatory Response
۱۲. Cytotoxic T Lymphocytes and Natural Killer Cells
۱۳. Regulatory Immune Cells
۱۴. Cytokines and Cytokine Receptors
۱۵. Chemokines and Chemokine Receptors
۱۶. Lymphocyte Adhesion and Trafficking
۱۷. Death Pathways and Immunogenicity
۱۸. Human Genomics in Immunology
۱۹. Regulatory RNA in Immunologic Diseases
۲۰. Immunometabolism
۲۱. Immune Deficiencies at the Extremes of Age
۲۲. The Microbiota in Immunity and Inflammation
۲۳. Immunology of the Skin
۲۴. Immunology of Mucosal Surfaces
۲۵. Host Defenses to Viruses
۲۶. Host Defenses to Intracellular Bacteria
۲۷. Host Defenses to Extracellular Bacteria Including Spirochetes
۲۸. Host Defenses to Fungi
۲۹. Host Defenses to Protozoa
۳۰. Host Defenses to Helminth Infection

More…

۷۰. Autoimmune Thyroid Diseases
۷۱. Type 1 Diabetes
۷۲. Immunologic Lung Diseases
۷۳. Chronic Obstructive Pulmonary Disease and Emphysema
۷۴. Immunologic Ocular Disease
۷۵. Immunologic Diseases of the Gastrointestinal Tract
۷۶. Inflammatory Hepatobiliary Diseases
۷۷. Lymphoid Leukemias
۷۸. Lymphomas
۷۹. Monoclonal Gammopathies
۸۰. Immune Responses to Solid Tumors and Immune Checkpoint Therapy
۸۱. CAR T-Cell Therapy
۸۲. Immunoglobulin Therapy: Replacement and Immunomodulation
۸۳. Glucocorticoids
۸۴. Immunomodulating Drugs
۸۵. Protein Kinase Antagonists
۸۶. Biologic Response Modifiers
۸۷. Vaccines
۸۸. Allergen Immunotherapy for Allergic Diseases
۸۹. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance
۹۰. Allogeneic Transplantation for Immunodeficiency
۹۱. Gene Therapy for Primary Immune Deficiency Diseases
۹۲. Hematopoietic Stem Cell Transplantation for Malignant Diseases
۹۳. Flow Cytometry
۹۴. Assessment of Functional Immune Responses in Lymphocytes
۹۵. Assessment of Neutrophil Function
۹۶. Assessment of Human Allergic Diseases