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Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9ed

Toxicology’s gold-standard text – completely updated to reflect the latest breakthroughs and discoveries 

A Doody’s Core Title for 2019!

Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere.

Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:

• General Principles of Toxicology
• Disposition of Toxicants
• Non-Organ Directed Toxicity
• Target Organ Toxicity
• Toxic Agents
• Environmental Toxicology
• Applications of Toxicology

Many new contributors capture the progress made in toxicology over the past few years:
This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book.

Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals.

About the Author

Contents

Chapter 1: The Evolving Journey of Toxicology: A Historical Glimpse
Chapter 2: Principles of Toxicology
Chapter 3: Mechanisms of Toxicity
Chapter 4: Risk Assessment
Chapter 5: Absorption, Distribution, and Excretion of Toxicants
Chapter 6: Biotransformation of Xenobiotics
Chapter 7: Toxicokinetics
Chapter 8: Chemical Carcinogenesis
Chapter 9: Genetic Toxicology
Chapter 10: Developmental Toxicology
Chapter 11: Toxic Responses of the Blood
Chapter 12: Toxic Responses of the Immune System
Chapter 13: Toxic Responses of the Liver
Chapter 14: Toxic Responses of the Kidney
Chapter 15: Toxic Responses of the Respiratory System
Chapter 16: Toxic Responses of the Nervous System
Chapter 17: Toxic Responses of the Cornea, Retina, and Central Visual System
Chapter 18: Toxic Responses of the Heart and Vascular System
Chapter 19: Toxic Responses of the Skin
Chapter 20: Toxic Responses of the Endocrine System
Chapter 21: Toxic Responses of the Reproductive System
Chapter 22: Toxic Effects of Pesticides
Chapter 23: Toxic Effects of Metals
Chapter 24: Toxic Effects of Solvents and Vapors
Chapter 25: Toxic Effects of Radiation and Radioactive Materials
Chapter 26: Toxic Effects of Plants and Animals
Chapter 27: Food Toxicology: Fundamental and Regulatory Aspects*
Chapter 28: Toxic Effects of Calories
Chapter 29: Nanoparticle Toxicology
Chapter 30: Ecotoxicology
Chapter 31: Air Pollution*
Chapter 32: Analytical and Forensic Toxicology
Chapter 33: Clinical Toxicology
Chapter 34: Occupational Toxicology
Chapter 35: Regulatory Toxicology