دانلود کتاب مرزهای تحقیقات دارویی بالینی – دیابت و چاقی
Frontiers in Clinical Drug Research – Diabetes and Obesity, Vol-3, 1ed

Frontiers in Clinical Drug Research – Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The third volume of this series features 5 chapters that cover a variety of topics including: -Exendin-4 and its derivatives -The growth hormone/insulin-like growth factor system -Insulin and cardiovascular function -Diabetes mellitus related infertility -Adipocytokines as markers of insulin resistance

Frontiers in Clinical Drug Research – Diabetes and Obesity Volume 3 comprises five comprehensive chapters on novel approaches to combat diabetes and obesity. In Chapter 1, Zhang et al. review the research on Extendin-4, a short peptide derived from lizard saliva, which has been used to treat diabetes and obesity. Insulin-like growth factor and growth hormone are two biochemical agents that play a role in diabetes and obesity. In Chapter 2, Moira S. Lewitt reviews the role of these two hormones in the management of diabetes and obesity.

Patients with long term diabetes suffer from heart problems and other organs are also affected. These problems have been attributed to physiological conditions brought about by the long term effects of insulin resistance on the body which result in hyperglycemic conditions and the presence of reactive oxygen species in mitochondria. In Chapter 3, Niels Juel Christensen presents a comprehensive review on insulin’s effects on capillary permeability in muscle endothelial cells and in podocytes in the kidney.

Contents

۱. Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope
۲. The Growth Hormone/Insulin-like Growth Factor System in the Management of Diabetes and Obesity
۳. Insulin, Cardiovascular Function and Long-Term Diabetic Complications
۴. Pharmacological Relevance of Novel Biomarkers Associated with Diabetes-mellitus Related Infertility
۵. Obesity and Type 2 Diabetes Mellitus: Adipocytokines as Markers of Insulin Resistance