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Voet Biochemistry, 4ed

Since the third edition of Biochemistry was published in 2004, the field of biochemistry has continued its phenomenal and rapidly accelerating growth. This remarkable expansion of our knowledge, the work of many thousands of talented and dedicated scientists, has been characterized by numerous new paradigms, as well as an enormous enrichment of almost every aspect of the field. For example, the number of known protein and nucleic acid structures as determined by X-ray and NMR techniques has increased by over 3-fold. Moreover, the quality and complexity of these structures, which include numerous membrane proteins, has significantly improved, thereby providing enormous advances in our understanding of structural biochemistry. Bioinformatics, an only recently coined word, has come to dominate the way that many aspects of biochemistry are conceived and practiced. Since the third edition of Biochemistry was published, the number of known genome sequences has increased by over 10-fold and the goal of personalized medicine to determine the genome sequence of each individual seems to be within reach. Likewise, the state of knowledge has exploded in such subdisciplines as eukaryotic and prokaryotic molecular biology, metabolic control, protein folding, electron transport, membrane transport, immunology, signal transduction, etc. New and improved methodologies such as DNA microarrays, rapid DNA sequencing, RNAi, cryoelectron microscopy, mass spectrometry, single molecule techniques, and robotic devices are now routinely used in the laboratory to answer questions that seemed entirely out of reach a decade ago. Indeed, these advances have affected our everyday lives in that they have changed the way that medicine is practiced, the way that we protect our own health, and the way in which food is produced.

The “Gold Standard” in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.

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Contents

CHAPTER 1 Life
CHAPTER 2 Aqueous Solutions
CHAPTER 3 Thermodynamic Principles: A Review
CHAPTER 4 Amino Acids
CHAPTER 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology
CHAPTER 6 Techniques of Protein and Nucleic Acid Purification
CHAPTER 7 Covalent Structures of Proteins and Nucleic Acids
CHAPTER 8 Three-Dimensional Structures of Proteins
CHAPTER 9 Protein Folding, Dynamics,and Structural Evolution
CHAPTER 10 Hemoglobin: Protein Function in Microcosm
CHAPTER 11 Sugars and Polysaccharides
CHAPTER 12 Lipids and Membranes
CHAPTER 13 Introduction to Enzymes
CHAPTER 14 Rates of Enzymatic Reactions
CHAPTER 15 Enzymatic Catalysis
CHAPTER 16 Introduction to Metabolism
CHAPTER 17 Glycolysis
CHAPTER 18 Glycogen Metabolism
CHAPTER 19 Signal Transduction
CHAPTER 20 Transport through Membranes
CHAPTER 21 Citric Acid Cycle
CHAPTER 22 Electron Transport and Oxidative Phosphorylation
CHAPTER 23 Other Pathways of Carbohydrate Metabolism
CHAPTER 24 Photosynthesis
CHAPTER 25 Lipid Metabolism
CHAPTER 26 Amino Acid Metabolism
CHAPTER 27 Energy Metabolism: Integration and Organ Specialization
CHAPTER 28 Nucleotide Metabolism
CHAPTER 29 Nucleic Acid Structures
CHAPTER 30 DNA Replication, Repair, and Recombination
CHAPTER 31 Transcription
CHAPTER 32 Translation
CHAPTER 33 Viruses: Paradigms for Cellular Functions
CHAPTER 34 Eukaryotic Gene Expression
CHAPTER 35 Molecular Physiology