دانلود کتاب رتینوئیدها: زیست شناسی، بیوشیمی و بیماری
The Retinoids: Biology, Biochemistry, and Disease, 1ed

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.

The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.

Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

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Contents

Chapter 1 Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms
Chapter 2 Assimilation and Conversion of Dietary Vitamin A into Bioactive Retinoids
Chapter 3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets
Chapter 4 Evolution of the Retinoic Acid Signaling Pathway
Chapter 5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational and Epigenetic Regulatory Mechanisms
Chapter 6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes
Chapter 7 Retinoid Receptors: Protein Structure, DNA Recognition and Structure-Function Relationships
Chapter 6 How the RAR-RXR Heterodimer Recognizes the Genome
Chapter 9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology
Chapter 10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner [SHP] Orphan Receptor
Chapter 11 The Dual Transcriptional Activity of Retinoic Acid
Chapter 12 Retinoids, Epigenetic Changes During Stem Cell Differentiation,and Cell Lineage Choice
Chapter 13 Retinoic Acid Signaling and Central Nervous System Development
Chapter 14 The Role of Retinoic Acid in Limb Development
Chapter 15 Retinoic Acid Signaling and Heart Development
Chapter 16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives
Chapter 17 Retinoic Acid and the Control of Meiotic Initiation
Chapter 18 Retinoids and the Visual Cycle: New Actors for an “Old” Function
Chapter 19 Retinoid Signaling in the Central Nervous System
Chapter 20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation
Chapter 21 Retinoids and the Immune System
Chapter 22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation
Chapter 23 Epidemiology and Prevention of Vitamin A Deficiency Disorders
Chapter 24 Retinoid Pathway Gene Mutations and the Pathophysiology of Related Visual Diseases
Chapter 25 Retinoic Acid in Acute Myeloid Leukemias
Chapter 26 Advances in the Use of Retinoids in Cancer Therapy and Prevention